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Menu
Home PageAll MoleculesHTT
HTT
HTT Overview
| English Name | Huntingtin | Approved Drugs | 0 |
| Drugs in Clinical Trials | 10 | Target Synonym | Huntingtin，HD protein，HD，HTT，Huntington Disease Protein，IT15，Huntingtin (Huntington Disease)，LOMARS，Huntingtin Protein |
| Highest Development Stage | Phase 3 Clinical | ||
| English Name | Huntingtin |
| Target Synonym | Huntingtin，HD protein，HD，HTT，Huntington Disease Protein，IT15，Huntingtin (Huntington Disease)，LOMARS，Huntingtin Protein |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 10 |
| Highest Development Stage | Phase 3 Clinical |
HTT Product List
- Product Category
Protein (1)
- Product Status
Launched (1)
- Species
Human (1)
- Tag
His Tag & MBP Tag (1)
- Conjugate
Unconjugated (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HTT-H51M5 |  Human | E. coli | Human HTT Protein, MBP,His Tag (MALS verified) |  |  |
Total: 1
- 1
HTT Background
Huntingtin is the protein coded for by the HTT gene. Autosomal dominant mutation in the Huntingtin (Htt) protein is the cause of Huntington’s Disease (HD). In HD, the polyglutamine (polyQ) domain in the N-terminal sequenceof the protein is expanded beyond a threshold of 36 glutamines. mutant polyQ expansion strongly correlates in an inverse manner to disease age of onset.
HTT Synonyms
HTT,Htt,Huntingtin
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Tominersen | RG-6042; RO-7234292; ISIS-443139 | Phase 3 Clinical | Ionis Pharmaceuticals Inc | Huntington Disease | Details |
| SKY-0515 | SKY-0515 | Phase 3 Clinical | Skyhawk Therapeutics Inc | Huntington Disease; Nervous System Diseases | Details |
| Votoplam | PTC-518; PTC518 | Phase 3 Clinical | Ptc Therapeutics Inc | Huntington Disease | Details |
| WVE-003 | WVE-003 | Phase 2 Clinical | Wave Life Sciences Ltd | Huntington Disease | Details |
| NA-841 | NA-841; NA841 | Phase 2 Clinical | Biomed Industries Inc | Huntington Disease | Details |
| SPK-10001 | SPK-10001; RG-6662; HTT miRNA GT | Phase 2 Clinical | Spark Therapeutics Inc | Huntington Disease | Details |
| ER-2001 | ER-2001; ER2001 | Phase 2 Clinical | Shenzhen Aima Biotechnology Co Ltd | Huntington Disease | Details |
| ARO-HTT | ARO-HTT; SRP-1005 | Phase 1 Clinical | Arrowhead Pharmaceuticals Inc | Huntington Disease | Details |
| ALN-HTT-02 | ALN-HTT-02; ALN-HTT02 | Phase 1 Clinical | Alnylam Pharmaceuticals Inc | Huntington Disease | Details |
| PTC-607 | PTC-607 | Phase 1 Clinical | Ptc Therapeutics Inc | Huntington Disease | Details |
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