언어 선택

Complement C3

Complement C3 분자 정보

영어 이름	Complement C3	시판 약물 수	1
임상 약물 수	13	표적 별명	Complement C3，Complement Component C3a，Epididymis Secretory Sperm Binding Protein Li 62p，C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1，C3bc，C3adesArg，C3，Complement Component C3b，Complement Component 3，C3a Anaphylatoxin，Prepro-C3，CPAMD1，Acylation-Stimulating Protein Cleavage Product，HEL-S-62p，AHUS5，ARMD9，ASP，C3a，C3b
최고 연구 개발 단계	Approved

영어 이름	Complement C3
표적 별명	Complement C3，Complement Component C3a，Epididymis Secretory Sperm Binding Protein Li 62p，C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1，C3bc，C3adesArg，C3，Complement Component C3b，Complement Component 3，C3a Anaphylatoxin，Prepro-C3，CPAMD1，Acylation-Stimulating Protein Cleavage Product，HEL-S-62p，AHUS5，ARMD9，ASP，C3a，C3b
시판 약물 수	1
임상 약물 수	13
최고 연구 개발 단계	Approved

Complement C3 제품 목록

속성
Protein (5)Kits (1)
제품 라이브러리
온라인 (6)
종
Human (4)Mouse (1)Cynomolgus (1)
태그
His Tag (3)His Tag & Avi Tag (1)Fc Tag (1)- (1)
마커
Unconjugated (4)Biotin-labeled (1)- (1)

제품 번호	종	발현 시스템	제품 설명
HOT CO3-H52H3	Human	HEK293	Human Complement C3 Protein, His Tag, low endotoxin (MALS verified)
HOT CO3-H82E8	Human	HEK293	Biotinylated Human Complement C3 Protein, His,Avitag™ (MALS verified)
HOT CO3-M52H4	Mouse	HEK293	Mouse Complement C3 Protein, His Tag (MALS verified)
CEA-B263	Human	-	Human Complement C3 ELISA Kit
CO3-H5253	Human	HEK293	Human Complement component 3 Protein, Fc Tag (MALS verified)
CO3-C52H5	Cynomolgus	HEK293	Cynomolgus Complement C3 Protein, His Tag (MALS verified)

총 수량6

Complement C3분자 배경

C3 is the major complement component serum. It is mainly synthesized by macrophages and liver. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. It is cleaved into two fragments, C3a and C3b. C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Complement C3분자 별명

Complement C3,CPAMD1

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Efdamrofusp alfa	IBI-302	Phase 3 Clinical	AP Biosciences Inc	Diabetic macular oedema; Macular Degeneration; Plaque psoriasis; Wet Macular Degeneration	상세
NGM-621	NGM-621	Phase 2 Clinical	NGM Biopharmaceuticals Inc	Coronavirus Disease 2019 (COVID-19); Geographic Atrophy	상세
RG-002-C-0106	RG-002-C-0106; RG002C0106	Phase 2 Clinical	Beijing Xuanjingrui Pharmaceutical Technology Co Ltd, Suzhou Xuanjing Biotechnology Co Ltd	Complement-Mediated Diseases; Glomerulonephritis, IGA; Hemolysis; Nephrotic Syndrome	상세
APL-3007	APL-3007	Phase 2 Clinical	Apellis Pharmaceuticals Inc	Geographic Atrophy	상세
SGB-9768	SGB-9768	Phase 2 Clinical	Suzhou Sanegene Bio Inc	C3 glomerulopathy; Glomerulonephritis; Glomerulonephritis, IGA; Glomerulonephritis, Membranoproliferative; Kidney Diseases	상세
KRIYA-825	KRIYA-825; VV-14295	Phase 2 Clinical	Kriya Therapeutics Inc	Geographic Atrophy	상세
ALXN-2030	ALXN-2030	Phase 2 Clinical	Alexion Pharmaceuticals Inc	Rejection of renal transplantation; Rejection of organ transplantation	상세
LP-005	LP-005; RX-001	Phase 2 Clinical	Longbio Pharma (Suzhou) Co Ltd	Amyotrophic Lateral Sclerosis; C3 glomerulopathy; Carcinoma, Non-Small-Cell Lung; Complement-Mediated Diseases; Glomerulonephritis, IGA; Glomerulonephritis, Membranoproliferative; Hemoglobinuria, Paroxysmal; Kidney Diseases; Lupus Nephritis; Myasthenia Gravis; Periodontal Diseases; Peripheral Nervous System Diseases; Thrombotic Microangiopathies	상세
ARO-C3	ARO-C3; ARO-C-3	Phase 2 Clinical	Arrowhead Pharmaceuticals Inc	C3 glomerulopathy; Glomerulonephritis, IGA	상세
CG-001	CG-001	Phase 1 Clinical	Chengdu Konjin Co Ltd	Autoimmune Diseases; Hemoglobinuria, Paroxysmal; Myasthenia Gravis	상세
BI-C		Phase 1 Clinical	Boehringer Ingelheim International Gmbh	Geographic Atrophy; Retinal Diseases	상세
Ebribafusp alfa	ADX-097	Phase 1 Clinical	Q32 Bio Inc	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Glomerulonephritis, IGA; Kidney Diseases; Lupus Nephritis; Nephrosis, Lipoid	상세
NM3086	NM3086; NM-3086	Phase 1 Clinical	NovelMed Therapeutics Inc	Hemoglobinuria, Paroxysmal	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Pegcetacoplan	APL-2	Approved	Apellis Pharmaceuticals Inc	Aspaveli, Empaveli, Syfovre	United States	Hemoglobinuria, Paroxysmal	Apellis Pharmaceuticals Inc	2021-05-14	Amyotrophic Lateral Sclerosis; Anemia, Hemolytic, Autoimmune; C3 glomerulopathy; Delayed Graft Function; Geographic Atrophy; Glomerulonephritis, IGA; Glomerulonephritis, Membranoproliferative; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Hemoglobinuria, Paroxysmal; Kidney Failure, Chronic; Lupus Nephritis; Macular Degeneration; Motor Neuron Disease; Rejection of renal transplantation	상세