언어 선택

COMP

COMP 분자 정보

영어 이름	Sodium channel protein type VIII alpha subunit	시판 약물 수	1
임상 약물 수	4	표적 별명	Sodium Channel， Voltage Gated， Type VIII Alpha Subunit，Voltage-Gated Sodium Channel Type VIII Alpha Protein，HNa6/Scn8a Voltage-Gated Sodium Channel，CERIII，EIEE13，Nav1.6，BFIS5，NaCh6，CIAT，PN4，NAV1.6 Voltage-Gated Sodium Channel，MYOCL2，Sodium channel protein type 8 subunit alpha，Sodium channel protein type VIII subunit alpha，MED，SCN8A，Sodium Voltage-Gated Channel Alpha Subunit 8，Sodium Channel， Voltage Gated， Type VIII， Alpha Subunit，Voltage-Gated Sodium Channel Subunit Alpha Nav1.6，Sodium Channel， Voltage Gated， Type VIII， Alpha Polypeptide
최고 연구 개발 단계	Approved

영어 이름	Sodium channel protein type VIII alpha subunit
표적 별명	Sodium Channel， Voltage Gated， Type VIII Alpha Subunit，Voltage-Gated Sodium Channel Type VIII Alpha Protein，HNa6/Scn8a Voltage-Gated Sodium Channel，CERIII，EIEE13，Nav1.6，BFIS5，NaCh6，CIAT，PN4，NAV1.6 Voltage-Gated Sodium Channel，MYOCL2，Sodium channel protein type 8 subunit alpha，Sodium channel protein type VIII subunit alpha，MED，SCN8A，Sodium Voltage-Gated Channel Alpha Subunit 8，Sodium Channel， Voltage Gated， Type VIII， Alpha Subunit，Voltage-Gated Sodium Channel Subunit Alpha Nav1.6，Sodium Channel， Voltage Gated， Type VIII， Alpha Polypeptide
시판 약물 수	1
임상 약물 수	4
최고 연구 개발 단계	Approved

COMP 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
COP-H5220	Human	HEK293	Human COMP / TSP5 Protein, His Tag

총 수량1

COMP분자 배경

Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.

COMP분자 별명

COMP,TSP5,EDM1,EPD1,MED,PSACH,THBS5

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
PRAX-562	PRAX-562	Phase 3 Clinical	Praxis Precision Medicines	Brain Diseases; Epilepsy	상세
XEN-901	NBI-921352; XEN-901	Phase 2 Clinical	Xenon Pharma	Epilepsies, Partial; Brain Diseases; Epilepsy	상세
PRAX-330	GS-458967; GS-967; PRAX-330	Phase 1 Clinical	Praxis Precision Medicines Inc	Epilepsy	상세
NBI-355	NBI-355	Phase 1 Clinical	Neurocrine Biosciences Inc	Epilepsy	상세