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CD8 alpha & beta

CD8 alpha & beta Overview

English Name	T-cell surface glycoprotein CD8 beta chain	Approved Drugs	0
Drugs in Clinical Trials	0	Target Synonym	CD8b，CD8b Molecule
Highest Development Stage	Preclinical

English Name	T-cell surface glycoprotein CD8 beta chain
Target Synonym	CD8b，CD8b Molecule
Approved Drugs	0
Drugs in Clinical Trials	0
Highest Development Stage	Preclinical

CD8 alpha & beta Product List

Product Category
Protein (6)
Product Status
Launched (6)
Species
Human (3)Cynomolgus (2)Mouse (1)
Tag
His Tag (4)His Tag & Avi Tag (2)
Conjugate
FITC Labeled (1)Unconjugated (3)Biotin-labeled (2)

Cat. No.	Species	Host	Product Description
HOT CDA-H52W5	Human	HEK293	Human CD8 alpha&beta (CD8A&CD8B) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)
HOT CDA-H82W7	Human	HEK293	Biotinylated Human CD8 alpha&beta (CD8A&CD8B) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)
HOT CDA-C52W3	Cynomolgus	HEK293	Cynomolgus CD8 alpha&beta (CD8A&CD8B) Heterodimer Protein, His Tag&Tag Free (MALS verified)
CDA-HF2W4	Human	HEK293	FITC-Labeled Human CD8 alpha&beta (CD8A&CD8B) Heterodimer Protein, His Tag&Tag Free
CDA-M52W3	Mouse	HEK293	Mouse CD8 alpha&beta (CD8A&CD8B) Heterodimer Protein, His Tag&Tag Free (MALS verified)
CDA-C82W3	Cynomolgus	HEK293	Biotinylated Cynomolgus CD8 alpha&beta (CD8A&CD8B) Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)

Total: 6

CD8 alpha & beta Background

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. CD8A forms disulfide-linked heterodimers with CD8B at the cell surface. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. Additionally, CD8B plays a critical role in thymic selection of CD8+ T-cells. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched.