언어 선택

CD46

CD46 분자 정보

영어 이름	Membrane cofactor protein	시판 약물 수	0
임상 약물 수	5	표적 별명	TLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Membrane cofactor protein
표적 별명	TLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544
시판 약물 수	0
임상 약물 수	5
최고 연구 개발 단계	Phase 2 Clinical

CD46 제품 목록

속성
Protein (5)
제품 라이브러리
온라인 (5)
종
Human (5)
태그
His Tag (4)Fc Tag (1)
마커
Unconjugated (2)FITC Labeled (1)APC Labeled (1)PE Labeled (1)

제품 번호	종	발현 시스템	제품 설명
CD6-H5226	Human	HEK293	Human CD46 Protein, His Tag, low endotoxin (MALS verified)
CD6-H5254	Human	HEK293	Human CD46 Protein, Fc Tag (MALS verified)
CD6-HA224	Human	HEK293	APC-Labeled Human CD46 Protein, His Tag
CD6-HF223	Human	HEK293	FITC-Labeled Human CD46 Protein, His Tag
CD6-HP223	Human	HEK293	PE-Labeled Human CD46 Protein, His Tag

총 수량5

CD46분자 배경

Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

CD46분자 별명

CD46,AHUS2,MCP,MIC10,TLX,TRA2.10

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Anti-CD46 antibody drug conjugate (Fortis Therapeutics)	FG-3246; FOR-46	Phase 2 Clinical	University Of California San Diego	Multiple Myeloma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	상세
Enadenotucirev	ColoAd-1; Oncolytic Ad11/Ad3	Phase 1 Clinical	Akamis Bio Ltd	Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Colorectal Neoplasms; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Rectal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Urinary Bladder Neoplasms	상세
AugmAb	BRM-132	Phase 1 Clinical	Compliment Corp	Lymphoma, Non-Hodgkin; Neoplasms	상세
YS-5	YS-5	Phase 1 Clinical	Fortis Therapeutics Inc, United States Department Of Defense	Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	상세
FG-3180	89Zr-DFO-YS-5; 89Zr-DFO-YS5	Phase 1 Clinical	Fortis Therapeutics Inc	Multiple Myeloma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	상세