CD43

CD43, also designated Ly-48, leukosialin, sialophorin, leukocyte sialoglycoprotein and W3/13, is a large type I transmembrane glycoprotein enriched with O-glycosylation and sialylation sites. It binds to CD54 (ICAM-1), CD62E, CD169 (Siglec-1), CD328 (Siglec-7) and MHC Class I molecules. Widely expressed on T lymphocytes, thymocytes, monocytes, granulocytes, bone marrow stem cells, pre-B cells, activated B cells and plasma cells—but absent on resting peripheral blood B cells, red blood cells and nonhematopoietic cells—CD43 modulates leukocyte functions (bidirectional adhesion, T cell costimulation, apoptosis induction) via intercellular interactions. Enzymatic shedding of activated leukocyte surface CD43 may exert negative regulation on adaptive immune responses, making it a valuable target for flow cytometry analysis.

leukosialin, sialophorin, GPL115, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein