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CD27

CD27 Overview

English Name	CD27 antigen	Approved Drugs	0
Drugs in Clinical Trials	4	Target Synonym	CD27 antigen，Tumor necrosis factor receptor superfamily member 7，CD27L receptor，CD27，CD27 Molecule，T-Cell Activation Antigen CD27，TNFRSF7，T14，T Cell Activation Antigen S152，S152. LPFS2，S152，Tp55，Tumor Necrosis Factor Receptor Superfamily， Member 7
Highest Development Stage	Phase 2 Clinical

English Name	CD27 antigen
Target Synonym	CD27 antigen，Tumor necrosis factor receptor superfamily member 7，CD27L receptor，CD27，CD27 Molecule，T-Cell Activation Antigen CD27，TNFRSF7，T14，T Cell Activation Antigen S152，S152. LPFS2，S152，Tp55，Tumor Necrosis Factor Receptor Superfamily， Member 7
Approved Drugs	0
Drugs in Clinical Trials	4
Highest Development Stage	Phase 2 Clinical

CD27 Product List

Product Category
Protein (6)
Product Status
Launched (6)
Species
Human (4)Cynomolgus / Rhesus macaque (1)Mouse (1)
Tag
Fc Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (3)His Tag (1)
Conjugate
Unconjugated (5)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HOT CD7-H522b	Human	HEK293	Human CD27 / TNFRSF7 Protein, His Tag (MALS verified)
HOT CD7-H5254	Human	HEK293	Human CD27 / TNFRSF7 Protein, Fc Tag (MALS verified)
HOT CD7-H5257	Human	HEK293	Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
HOT TN7-H82F6	Human	HEK293	Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™
HOT CD7-M5252	Mouse	HEK293	Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
HOT CD7-C5259	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)

Total: 6

CD27 Background

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27 Synonyms

CD27,TNFRSF7,S152,T14,Tp55

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Varlilumab	CDX-1127	Phase 2 Clinical	Celldex Therapeutics	Adenocarcinoma; Astrocytoma; Bile Duct Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Central Nervous System Lymphoma; Cholangiocarcinoma; Gallbladder Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hormone-Resistant Prostate Neoplasms; Kidney Diseases; Kidney Neoplasms; Large intestine neoplasm; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, T-Cell; Lung Neoplasms; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, Primary Effusion; Lymphoma, T-Cell; Lymphomatoid Granulomatosis; Melanoma; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Plasmablastic Lymphoma; Prostatic Neoplasms; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Urologic Diseases; Urologic Neoplasms	Details
Boserolimab	MK-5890	Phase 1 Clinical	BioNovion Holding BV	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Solid tumours; Triple Negative Breast Neoplasms	Details
LOR-S03	CDX-527	Phase 1 Clinical	Celldex Therapeutics	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours; Stomach Neoplasms	Details
Anti-CD27 monoclonal antibody (Aduro Biotech)	BION-1402	Phase 1 Clinical	Aduro Biotech Inc	Neoplasms	Details