CD27

CD27

CD27 Overview

Molecule Name
CD27 antigen
Synonyms
CD27,TNFRSF7,S152,T14,Tp55
Drug Development Progress
Drugs in Clinical Trials4
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
CD27 antigen,Tumor necrosis factor receptor superfamily member 7,CD27L receptor,CD27,CD27 Molecule,T-Cell Activation Antigen CD27,TNFRSF7,T14,T Cell Activation Antigen S152,S152. LPFS2,S152,Tp55,Tumor Necrosis Factor Receptor Superfamily, Member 7
Background
CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27 Product List

Species
  • Human(4)
  • Cynomolgus / Rhesus macaque(1)
  • Mouse(1)
Tag
  • Mouse IgG Fc Tag(3)
  • Fc Tag(1)
  • Fc Tag & Avi Tag(1)
  • His Tag(1)
Host
  • HEK293(6)
Conjugate
  • Unconjugated(5)
  • Biotin-labeled(1)
Grade
  • RUO(6)
Low Endotoxin
  • Yes(3)
  • No(3)
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
CD27
Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
Mouse
HEK293
MALSSDS-PAGE
ELISA

$395.00

100ug
CD27
HOTAvitag
TN7-H82F6
Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™
Human
HEK293
SDS-PAGE
ELISAFlow

$360.00

25ug
CD27
Human CD27 / TNFRSF7 Protein, His Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$395.00

100ug
CD27
Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$360.00

100ug
CD27
Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
Cynomolgus / Rhesus macaque
HEK293
MALSSDS-PAGE
ELISA

$395.00

100ug
CD27
Human CD27 / TNFRSF7 Protein, Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$310.00

200ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
VarlilumabCDX-1127Phase 2 ClinicalCelldex Therapeutics
Adenocarcinoma; Astrocytoma; Bile Duct Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Central Nervous System Lymphoma; Cholangiocarcinoma; Gallbladder Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hormone-Resistant Prostate Neoplasms; Kidney Diseases; Kidney Neoplasms; Large intestine neoplasm; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, T-Cell; Lung Neoplasms; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, Primary Effusion; Lymphoma, T-Cell; Lymphomatoid Granulomatosis; Melanoma; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Plasmablastic Lymphoma; Prostatic Neoplasms; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Urologic Diseases; Urologic Neoplasms
Details
BoserolimabMK-5890Phase 1 ClinicalBioNovion Holding BV
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Solid tumours; Triple Negative Breast Neoplasms
Details
LOR-S03CDX-527Phase 1 ClinicalCelldex Therapeutics
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Liver Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours; Stomach Neoplasms
Details
Anti-CD27 monoclonal antibody (Aduro Biotech)BION-1402Phase 1 ClinicalAduro Biotech Inc
Neoplasms
Details
Customer Reviews