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CD14

CD14 Overview

English Name	Monocyte differentiation antigen CD14	Approved Drugs	0
Drugs in Clinical Trials	3	Target Synonym	CD14，CD14 Molecule，Myeloid Cell-Specific Leucine-Rich Glycoprotein，CD14 Antigen，Monocyte Differentiation Antigen CD14
Highest Development Stage	Phase 2 Clinical

English Name	Monocyte differentiation antigen CD14
Target Synonym	CD14，CD14 Molecule，Myeloid Cell-Specific Leucine-Rich Glycoprotein，CD14 Antigen，Monocyte Differentiation Antigen CD14
Approved Drugs	0
Drugs in Clinical Trials	3
Highest Development Stage	Phase 2 Clinical

CD14 Product List

Product Category
Protein (3)Cell Grade Beads (1)Antibody (2)
Product Status
Launched (6)
Species
Human (4)Mouse (2)
Tag
His Tag (1)Fc Tag (1)His Tag & Avi Tag (1)- (3)
Conjugate
Unconjugated (2)Biotin-labeled (1)- (1)PE Labeled (1)APC Labeled (1)

Cat. No.	Species	Host	Product Description
HOT CD4-H5252	Human	HEK293	Human CD14 Protein, Fc Tag (MALS verified)
HOT CD4-H8228	Human	HEK293	Biotinylated Human CD14 Protein, His,Avitag™
HOT MBS-S001	Human	HEK293	Cellectra™ Human CD14 NanoSort Microbeads, Research grade
CD4-H5228	Human	HEK293	Human CD14 Protein, His Tag (MALS verified)
CD4-AMY2061	Mouse	HEK293	APC-Labeled Monoclonal Anti-Human CD14 Antibody, Mouse IgG1 (20F9E3) (0.03% Proclin)
CD4-PMY2061	Mouse	HEK293	PE-Labeled Monoclonal Anti-Human CD14 Antibody, Mouse IgG1 (20F9E3) (0.03% Proclin)

Total: 6

CD14 Background

Cluster of differentiation 14 (CD14), is a cell surface glycoprotein, and is a is a component of the innate immune system. CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa). CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial Cluster of differentiation 14 (CD14), is a cell surface glycoprotein, and is a is a component of the innate immune system. CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa). CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial.

CD14 Synonyms

CD14

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Atibuclimab	IC-14	Phase 2 Clinical	Icos Corporation	Acute Lung Injury; Acutely decompensated congestive heart failure; Amyotrophic Lateral Sclerosis; Arrhythmias, Cardiac; Arrhythmogenic Right Ventricular Dysplasia; Cardiomyopathies; Coronavirus Disease 2019 (COVID-19); Dengue; Lung Diseases; Motor Neuron Disease; Pneumonia; Respiratory Distress Syndrome, Adult; Sepsis; ST Elevation Myocardial Infarction	Details
VB-201	CI-201; VB-201	Phase 2 Clinical	Notable Labs Ltd	Cardiovascular Diseases; Colitis, Ulcerative; Coronavirus Disease 2019 (COVID-19); HIV Infections; Inflammation; Plaque psoriasis; Psoriasis	Details
TCP-25	TCP-25	Phase 2 Clinical	Lund University	Blister; Epidermolysis Bullosa; Epidermolysis Bullosa Dystrophica; Epidermolysis Bullosa, Junctional; Wounds and Injuries	Details