언어 선택

CD109

CD109 분자 정보

영어 이름	DNA polymerase alpha subunit	시판 약물 수	2
임상 약물 수	3	표적 별명	P180，N Syndrome (Mental Retardation， Malformations， Chromosome Breakage)，NSX，VEODS，Polymerase (DNA Directed)， Alpha，POLA1，Polymerase (DNA-Directed)， Alpha (70kD)，DNA Polymerase Alpha 1， Catalytic Subunit，POLA，EC:2.7.7.7，EC 2.7.7.7，DNA Polymerase Alpha Catalytic Subunit，DNA Polymerase Alpha Catalytic Subunit P180，Polymerase (DNA) Alpha 1， Catalytic Subunit，DNA Polymerase I，Polymerase (DNA Directed)， Alpha 1， Catalytic Subunit
최고 연구 개발 단계	Approved

영어 이름	DNA polymerase alpha subunit
표적 별명	P180，N Syndrome (Mental Retardation， Malformations， Chromosome Breakage)，NSX，VEODS，Polymerase (DNA Directed)， Alpha，POLA1，Polymerase (DNA-Directed)， Alpha (70kD)，DNA Polymerase Alpha 1， Catalytic Subunit，POLA，EC:2.7.7.7，EC 2.7.7.7，DNA Polymerase Alpha Catalytic Subunit，DNA Polymerase Alpha Catalytic Subunit P180，Polymerase (DNA) Alpha 1， Catalytic Subunit，DNA Polymerase I，Polymerase (DNA Directed)， Alpha 1， Catalytic Subunit
시판 약물 수	2
임상 약물 수	3
최고 연구 개발 단계	Approved

CD109 제품 목록

속성
Protein (4)
제품 라이브러리
온라인 (4)
종
Human (3)Cynomolgus (1)
태그
His Tag & Avi Tag (1)His Tag (2)Fc Tag (1)
마커
Biotin-labeled (1)Unconjugated (3)

제품 번호	종	발현 시스템	제품 설명
CD9-H5256	Human	HEK293	Human CD109 / CPAMD7 protein, Fc Tag
CD9-H52H3	Human	HEK293	Human CD109 / CPAMD7 Protein, His Tag
CD9-H82E4	Human	HEK293	Biotinylated Human CD109 / CPAMD7 Protein, His,Avitag™ (MALS & SPR verified)
CD9-C52H5	Cynomolgus	HEK293	Cynomolgus CD109 / CPAMD7 Protein, His Tag

총 수량4

CD109분자 배경

CD109 is a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. CD109 is expressed in many malignant tumors, including various squamous cell carcinomas and adenocarcinomas, and plays a role as a multifunctional coreceptor.CD109 reportedly associates with transforming growth factor (TGF)-β receptors and negatively regulates TGF-β signaling in keratinocytes. Additionally, CD109 is potentially related to signal transducer and activator of transcription-3 signaling and aberrant cell proliferation.

CD109분자 별명

CD109,CPAMD7,r150,p180,CPAMD7

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Clofarabine (Boyen)	BY-101	Phase 3 Clinical	Boyen Therapeutics Inc	Leukemia, Myeloid, Acute	상세
Alkasar-18	NOAC; Alkasar-18; N4-octadecyl-ara-C	Phase 1 Clinical	University of Zurich	Cerebral Hemorrhage; Neoplasms; Atrial Fibrillation	상세
Sapacitabine	CS-682; CYC-682	Phase 1 Clinical	Daiichi Sankyo Co Ltd	Leukemia; Myelodysplastic Syndromes; Breast Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous; Carcinoma, Non-Small-Cell Lung	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Clofarabine	CAFdA; JC0707; GZ-393590; SAR-393590; 2-Cl-2-F-araA	Approved	Genzyme Corp	Clolar, Evoltra, Ivozall, Clofarex	United States	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Genzyme Corp	2004-12-28	Neoplasms; Angioimmunoblastic T-cell Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell; Waldenstrom Macroglobulinemia; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Lymphoma; Lymphoproliferative Disorders; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Histiocytosis, Langerhans-Cell; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Multiple Myeloma; Leukemia; Lymphoma, Large B-Cell, Diffuse; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Leukemia, Lymphoid; Intestinal Neoplasms; Lymphoma, T-Cell, Peripheral; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Hematologic Neoplasms; Leukemia, Myeloid; Leukemia, Myelogenous, Chronic; Solid tumours	상세
Nelarabine	506U; 506-U78; GW-506U; GW-506U78; GI-262250X; NSC-686673	Approved	Novartis Pharma Ag, Glaxosmithkline Plc	Arranon, ArranonG, Atriance	United States	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Sandoz	2005-10-28	Sezary Syndrome; Mycosis Fungoides; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, T-Cell; Angioimmunoblastic T-cell Lymphoma; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Cutaneous; Waldenstrom Macroglobulinemia; Lymphoma, T-Cell; Lymphoma, Non-Hodgkin; Lymphoma; Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Follicular; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Multiple Myeloma; Leukemia-Lymphoma, Adult T-Cell; Myeloproliferative Disorders; Myelodysplastic Syndromes; Plasmacytoma; Lymphoma, B-Cell, Marginal Zone	상세