언어 선택

ACHE

ACHE 분자 정보

영어 이름	Acetylcholinesterase	시판 약물 수	27
임상 약물 수	31	표적 별명	EC:3.1.1.7，EC 3.1.1，Acetylcholinesterase (YT Blood Group)，Acetylcholinesterase (Cartwright Blood Group)，Yt Blood Group，Apoptosis-Related Acetylcholinesterase，Acetylcholinesterase，EC 3.1.1.7，ARACHE，N-ACHE，ACEE，AChE，YT
최고 연구 개발 단계	Approved

영어 이름	Acetylcholinesterase
표적 별명	EC:3.1.1.7，EC 3.1.1，Acetylcholinesterase (YT Blood Group)，Acetylcholinesterase (Cartwright Blood Group)，Yt Blood Group，Apoptosis-Related Acetylcholinesterase，Acetylcholinesterase，EC 3.1.1.7，ARACHE，N-ACHE，ACEE，AChE，YT
시판 약물 수	27
임상 약물 수	31
최고 연구 개발 단계	Approved

ACHE 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
AHE-H52H3	Human	HEK293	Human ACHE / Acetylcholinesterase Protein, His Tag (active enzyme)

총 수량1

ACHE분자 배경

The enzyme acetylcholinesterase, also known as AChE or acetylhydrolase, is the primary cholinesterase in the body. It is a serine hydrolase whose primary function is to catalyzes the breakdown of acetylcholine(ACh) and of some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. Acetylcholine deficit has been found in Alzheimer's disease (AD) ans is associated with cognetive decline. Therefore, AChE has been reported to be a viable therapeutic target for the treatment of AD and other dementias. To this end, acetylcholinesterase inhibitors (AChEIs) are commonly used.

ACHE분자 별명

acetylcholinesterase (Yt blood group),Acetylcholinesterase,ACHE,apoptosis-related acetylcholinesterase,ARACHE,EC 3.1.1,EC 3.1.1.7,N-ACHE,Yt blood group,YT

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Donepezil/Solifenacin	CPC-201	Phase 3 Clinical	Allergan Plc, Cipla Inc	Alzheimer Disease; Dementia; Urologic Diseases	상세
Botulinum toxin (CKD Bio)	CKDB-501B; CKDB-501-B; CKDB-501A; CKDB-501-A; CKDB-501	Phase 3 Clinical	CKD Bio Corp	Glabellar lines; Spasm	상세
BR-4001	BNT-002; BR-4001	Phase 3 Clinical	Boryung Pharmaceutical Co Ltd	Alzheimer Disease	상세
Blarcamesine/Donepezil Hydrochloride		Phase 2 Clinical	Anavex Life Sciences Corp	Alzheimer Disease	상세
Pregnenolone	NBI-113	Phase 2 Clinical	Neurocrine Biosciences Inc	Alcoholism; Anxiety; Autism Spectrum Disorder; Autistic Disorder; Cocaine-Related Disorders; Depression; Depressive Disorder, Major; Low Back Pain; Menopausal symptoms; Schizophrenia; Stress Disorders, Post-Traumatic	상세
Fluoropezil	DC-20; DC-511020	Phase 2 Clinical	Jiangsu Kanion Pharmaceutical Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Alzheimer Disease	상세
Pyridostigmine extended release (Kashiv BioSciences)	K-127	Phase 2 Clinical	Kashiv BioSciences LLC	Blepharoptosis; Fatigue Syndrome, Chronic; Musculoskeletal Diseases; Myasthenia Gravis; Post-Acute COVID-19 Syndrome; Urination Disorders	상세
Donepezil long-acting Injection (Inventage Lab)	IVL-3003	Phase 2 Clinical	Inventage Lab Inc	Alzheimer Disease	상세
YY-003	YY003; YY-003	Phase 2 Clinical	Chongqing Claruvis Pharmaceutical Co Ltd	Glabellar lines	상세
AT-004(Arctic Therapeutics)	AT-004(Arctic Therapeutics)	Phase 2 Clinical	Arctic Therapeutics International	Acne Vulgaris; Dermatitis, Atopic; Psoriasis; Rosacea	상세
Galantamine/Metformin	RJx-01	Phase 2 Clinical	Rejuvenate Biomed NV	Muscle Weakness; Muscular Atrophy; Sarcopenia	상세
Huperizine-A (Biscayne Pharmaceuticals)	BIS-001; INS-001; XEL-001-HP; SPN-817; BIS-001-ER; XEL-001-HG; Hup-A	Phase 2 Clinical	Harvard University	Epilepsy, Complex Partial; Seizures	상세
EX-039	EX-039	Phase 2 Clinical	Excelsior Corp	Alzheimer Disease	상세
donepezil (Vyant Bio)	VYNT-0126	Phase 2 Clinical	Vyant Bio Inc	Rett Syndrome	상세
YIV-906	PHY-906; KD-018	Phase 2 Clinical	Phytoceutica Inc	Carcinoma, Hepatocellular; Colorectal Neoplasms; Diarrhea; Hepatitis B; Liver Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms	상세
AD-35	AD-35	Phase 2 Clinical	Zhejiang Hisun Pharmaceutical Co Ltd	Alzheimer Disease	상세
Edrophonium Chloride		Phase 1 Clinical	Teligent	Myasthenia Gravis	상세
18F-flubatine	Fluorine-18-flubatine; flubatine-[18F]; 18F-flubatine; norchloro-fluoroepibatidine-[18F]	Phase 1 Clinical	Helmholtz-Zentrum Dresden-Rossendorf	Alzheimer Disease	상세
Phenserine tartrate	DWJ301	Phase 1 Clinical	Qr Pharma	Alzheimer Disease; Cognitive Dysfunction	상세
Mecripyrine Hydrochloride	SCR-1693; Y-1A; Y-1	Phase 1 Clinical	Jiangsu Simcere Pharmaceutical Co Ltd, NeuroDawn Pharmaceutical Co Ltd, Yantai Yene Pharma Co Ltd	Alzheimer Disease; Brain Neoplasms	상세
Methanesulfonyl fluoride	SNX-001	Phase 1 Clinical	Senexta	Alzheimer Disease	상세
NB-02	NB-02; DA-9803	Phase 1 Clinical	Dong-A ST Co Ltd	Alzheimer Disease; Lymphoma, Non-Hodgkin	상세
NDC-011	NDC-011	Phase 1 Clinical	Dr. Noah Biotech Inc	Amyotrophic Lateral Sclerosis	상세
Donepel hydrochloride oral instant membrane(Sichuan Baili Pharma)		Phase 1 Clinical	Sichuan Baili Pharmaceutical Co Ltd	Alzheimer Disease	상세
Donepezil Hydrochloride Oral Soluble Film(Shanxi Hcxf Pharma)		Phase 1 Clinical	Shanxi Hcxf Pharmaceutical Co Ltd	Alzheimer Disease	상세
Donepezil Hydrochloride Oral Soluble Film(Hangzhou Heze Pharma)	HZ007; HZ-007	Phase 1 Clinical	Hangzhou Heze Pharmaceutical Technology Co Ltd	Alzheimer Disease; Dementia	상세
Huperzine A Oral Solution(Universal Pharmaceutical Group)		Phase 1 Clinical	Universal Pharmaceutical Group Co Ltd	Myasthenia Gravis	상세
Donepezil transdermal patch（Dong-A ST）	DA-5207	Phase 1 Clinical	Dong-A ST Co Ltd		상세
HHT-201	HHT-201	Phase 1 Clinical	Zhejiang Huahai Pharmaceutical Co Ltd	Alzheimer Disease; Hypertension	상세
Rivastigmine (Lachesis Biosciences Pty)		Clinical	Lachesis Biosciences Pty Ltd	Nerve Degeneration	상세
donepezil (Daewoong)	DWJ-1365	Clinical	Daewoong Pharmaceutical Co Ltd	Alzheimer Disease	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Galantamine Hydrobromide	GP-37267; R-113675	Approved		AverTox, Nivalin, Reminyl, Razadyne, Reminyl XL	Mainland China	Alzheimer Disease	null	1981-01-01	AIDS Dementia Complex; Alzheimer Disease; Autistic Disorder; Bipolar Disorder; Brain Diseases; Cocaine-Related Disorders; Cognition Disorders; Dementia; Dementia, Vascular; Depressive Disorder, Major; Fasting; Frontotemporal Dementia; Insulin Resistance; Lewy Body Disease; Memory; Mental Disorders; Nervous System Diseases; Obesity; Schizophrenia; Stroke; Subarachnoid Hemorrhage; Tobacco Use Disorder; Vascular Diseases	상세
Neostigmine Bromide		Approved		Prostigmin	Mainland China	Flatulence; Urinary Retention; Myasthenia Gravis	Shanghai Sine Pharmaceutical Laboratories Co Ltd	1995-01-01	Delayed Emergence from Anesthesia; Flatulence; Headache; Hypertension; Hyperventilation; Hypoxia; Myasthenia Gravis; Tachycardia; Urinary Retention	상세
Metrifonate	Bay-a-9826; Bayer-L-1359	Approved		ProMem, Memobay, Bilarcil					Schistosomiasis	상세
Rivastigmine Tartrate	SDZ-212-713; SDZ 212713; SDZ-ENA-713; ONO-2540; ENA-713; ENA-713D	Approved	Novartis Pharma Ag	Exelon TDS, Rivastach, Exelon MR, Prometax, Exelon, 艾斯能	EU	Alzheimer Disease; Parkinson Disease; Dementia	Novartis Europharm Ltd	1998-05-11	Alzheimer Disease; Anticholinergic Syndrome; Brain Injuries, Traumatic; Cocaine-Related Disorders; Cognition Disorders; Delirium; Dementia; Dementia, Vascular; Down Syndrome; Neurobehavioral Manifestations; Parkinson Disease; Substance-Related Disorders	상세
Pyridostigmine Bromide	Ro-1-5130	Approved	Valeant	Regonol, Mestinon	United States	Lambert-Eaton Myasthenic Syndrome	Bausch & Lomb (Singapore) Pvi Ltd	1955-04-06	Colonic Diseases; Constipation; Coronavirus Disease 2019 (COVID-19); Diabetes Mellitus; Dyskinesias; Fatigue Syndrome, Chronic; Fibromyalgia; Glycogen Storage Disease Type II; Heart Failure; HIV Infections; Hypotension, Orthostatic; Immunologic Deficiency Syndromes; Lambert-Eaton Myasthenic Syndrome; Myasthenia Gravis; Parkinson Disease; Poisoning; Postural Orthostatic Tachycardia Syndrome; Primary Dysautonomias; Scleroderma, Systemic; T-Lymphocytopenia, Idiopathic CD4-Positive	상세
Dimebolin hydrochloride	BRN-0622478; PF-01913539; DMB-I	Approved	Bigespas Ltd	Dimebon	Russian Federation	Hypersensitivity; Rhinitis, Allergic; Dermatitis, Atopic	null	1983-01-01	Alzheimer Disease; Dementia; Dermatitis, Atopic; Huntington Disease; Hypersensitivity; Liver Failure; Rhinitis, Allergic	상세
Donepezil Hydrochloride	DKF-310; BNAG; E-2020; E-2022; (±)-E-2020; IVL-3003; GB-5001	Approved	Eisai Co Ltd	Memac, Eranz, Memorit, Aricept Evess, Aricept, Aricept ODT, Aricept D, 安理申, ADLARITY	United States	Alzheimer Disease	Eisai Inc	1996-11-25	Alcoholism; Alzheimer Disease; Anorexia Nervosa; Anxiety Disorders; Aphasia; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Autistic Disorder; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Central Nervous System Neoplasms; CNS Embryonal Tumor; Cognition Disorders; Cognitive Dysfunction; Delirium; Dementia; Dementia, Vascular; Depression; Diabetes Mellitus, Type 2; Down Syndrome; Fatigue; Fragile X Syndrome; Hearing Loss, Sensorineural; Ischemic Stroke; Lewy Body Disease; Memory Disorders; Migraine Disorders; Multiple Sclerosis; Neoplasms; Neurologic Manifestations; Neurotoxicity Syndromes; Osteoporosis; Parkinson Disease; Psychological Distress; Sleep Wake Disorders; Stroke; Subarachnoid Hemorrhage; Supranuclear Palsy, Progressive; Wounds and Injuries	상세
Memantine Hydrochloride/Donepezil Hydrochloride	ADS-8704; D-797/D-324; CKD 355; BPS-034; BPDO-1603; MDX-8704	Approved	Allergan Plc	Arimenda, Namzaric	United States	Alzheimer Disease	Abbvie Inc	2014-12-23	Alzheimer Disease	상세
Huperzine A	SPN-817	Approved	Chinese Academy Of Sciences, Mayo Clinic	哈伯因, 双益平	Mainland China	Alzheimer Disease	Henan Taloph Pharmaceutical Stock Co Ltd	1994-01-01	Alzheimer Disease; Brain Injuries, Traumatic; Epilepsy; Learning Disabilities; Memory Disorders; Schizophrenia; Seizures	상세
Distigmine Bromide	BC-51	Approved	Torii Pharmaceutical Co Ltd	Ubretid	Japan	Dysuria; Myasthenia Gravis	Torii Pharmaceutical Co Ltd	1967-09-05	Dysuria; Esotropia; Glaucoma; Myasthenia Gravis	상세
Pralidoxime Chloride	2-PAM-chloride	Approved	Baxter International Inc	Protopam chloride	United States	Poisoning	Baxter Healthcare Corp	1964-03-11	Poisoning	상세
Pralidoxime Iodide	2-PAMI; NSC-7760; 2-PAM Iodide	Approved			Japan	Poisoning	Sumitomo Dainippon	1958-05-01	Poisoning	상세
Eserine Salicylate		Approved		Synapton SR, Xalieve, Antilirium					Delirium; Glaucoma; Insulin Resistance; Pain, Postoperative; Psychotic Disorders	상세
Neostigmine methylsulfate		Approved		Bloxiverz, Intrastigmina, Juvastigmin, Stiglyn, Metastigmin	Japan	Myasthenia Gravis; Muscle Hypotonia	kyowayakuhin Co	1936-10-01	Flatulence; Muscle Hypotonia; Myasthenia Gravis; Neuromuscular Blockade; Urinary Retention	상세
Naphazoline Hydrochloride/Neostigmine methylsulfate/Glycyrrhizinate dipotassium/Chlorphenamine Maleate/Aspartic Acid/Vitamin B6		Approved		新乐敦						상세
Dextrose/Sodium Chloride/Potassium Chloride/Floxacillin sodium		Approved								상세
Dextrose/Sodium Chloride/Potassium Chloride/Anthralin		Approved								상세
Dextrose/Sodium Chloride/Potassium Chloride/Pralidoxime Chloride		Approved								상세
Pralidoxime Chloride/Benactyzine Hydrochloride/Atropine Sulfate		Approved							Poisoning	상세
Naphazoline Hydrochloride/Neostigmine methylsulfate		Approved								상세
Dihydrogalanthamine Hydrobromide		Approved			Mainland China	Hemiplegia; Sciatica	null	1982-01-01	Hemiplegia; Sciatica	상세
Securinine Nitrate		Approved							Facial Paralysis; Poliomyelitis	상세
Rivastigmine Twice Weekly Transdermal Patch (Luye Pharma)	LY-03013; LY-30410; RID-TDS	Approved	Acino International AG	Rivirec, 金斯明, Kingsmin, Rivalif®	Mainland China	Alzheimer Disease	Luye Pharma Group Ltd		Alzheimer Disease; Parkinson Disease	상세
Glycopyrronium bromide/Neostigmine metilsulfate		Approved	Sintetica Gmbh	Novistig, Prevduo	Austria	Neuromuscular Blockade	Sintetica Gmbh	2020-09-23	Neuromuscular Blockade	상세
Benzgalantamine gluconate	GLN-1062; ALPHA-1062; ALPHA-1062IN; Alpha 1062; ALPHA-1062 Intranasal	Approved	Galantos Pharma GmbH	Zunveyl	United States	Alzheimer Disease	Alpha Cognition Inc	2024-07-26	Alzheimer Disease; Brain Injuries, Traumatic; Cognitive Dysfunction	상세
Atropine/Pralidoxime Chloride		Approved	Meridian Medical Technologies Inc	DUODOTE	United States	Poisoning; Organophosphate Poisoning	Meridian Medical Technologies LLC	2002-01-17	Drug intoxications; Drug-Related Side Effects and Adverse Reactions; Organophosphate Poisoning; Poisoning	상세
Acotiamide Hydrochloride Hydrate	Z-338; YM-443	Approved	Zeria	Acofide	Japan	Dyspepsia	null	2013-03-25	Dyspepsia; Nausea	상세