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LRRC32 & TGF-beta 1,LRRC32&TGFB1
Cynomolgus LRRC32&TGF-beta 1 Heterotrimer Protein, His Tag&Tag Free (GA1-C52W6) is expressed from human 293 cells (HEK293). It contains AA Ala 18 - Asn 627 (LRRC32) & Leu 30 - Ser 362 (TGF-beta 1) (Accession # A0A2K5X2X9-1(LRRC32) & A0A2K5TJB2-1(TGF-beta 1)).
Predicted N-terminus: Ala 18 (LRRC32) & Leu 30 (TGF-beta 1)
Cynomolgus LRRC32&TGFB1 Heterotrimer protein, His Tag&Tag Free (the molar ratio of LRRC32 & TGF-beta 1 equals 1:2) is produced by co-expression of LRRC32 and TGF-beta 1, which has a calculated MW of 68.1 kDa (LRRC32), 26.7 (LAP) and 11.3 kDa (mature TGF-beta 1) respectively. LRRC32 is fused with a polyhistidine tag at the C-terminus and TGF-beta 1 contains no tag.
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GARP (LRRC32) is a transmembrane protein that binds latent-TGF-β1 and tethers it on the Treg surface. and has been proved to promote the activation and secretion of transforming growth factor β (TGF-β). The expression of GARP is highly on the surface activated Tregs and increases the suppressive function of Tregs. Additionally, GARP can bind to latent transforming growth factor β (TGF-β), thus promoting secretion and activation of TGF-β. TGF-β plays a critical rule for homeostasis and function of Tregs. Notably, it has been also observed that fibroblasts and endothelial cell lines that express GARP/latent TGF-β1 complexes do not activate TGF-β1. However, it cannot be excluded that specific stimuli are required to trigger TGF-β1 activation from complexes on the surface of these cell types.