언어 선택

IL-1 beta

IL-1 beta 분자 정보

영어 이름	Interleukin-1 beta	시판 약물 수	10
임상 약물 수	17	표적 별명	IL1-BETA，IL-1，Interleukin-1beta，IL-1B，IL-1β，IL-1 β，IL1beta，Interleukin 1beta，Catabolin，IL-1 beta，IL1B，Interleukin 1 Beta，IL1F2，Pro-Interleukin-1-Beta，Preinterleukin 1 Beta，Interleukin-1 Beta
최고 연구 개발 단계	Approved

영어 이름	Interleukin-1 beta
표적 별명	IL1-BETA，IL-1，Interleukin-1beta，IL-1B，IL-1β，IL-1 β，IL1beta，Interleukin 1beta，Catabolin，IL-1 beta，IL1B，Interleukin 1 Beta，IL1F2，Pro-Interleukin-1-Beta，Preinterleukin 1 Beta，Interleukin-1 Beta
시판 약물 수	10
임상 약물 수	17
최고 연구 개발 단계	Approved

IL-1 beta 제품 목록

속성
Protein (8)Kits (2)
제품 라이브러리
온라인 (10)
종
Human (8)Mouse (1)Cynomolgus (1)
태그
Tag Free (3)Fc Tag (1)His Tag (3)His Tag & Avi Tag (1)- (2)
마커
Unconjugated (7)Biotin-labeled (1)- (2)

제품 번호	종	발현 시스템	제품 설명
HOT CRS-B002	Human	-	Human IL-1β ELISA Kit
HOT GMP-ILBH16	Human	E. coli	GMP Human IL-1 beta Protein
HOT ILB-H4110	Human	E. coli	Human IL-1 beta / IL-1F2 Protein, premium grade
HOT ILB-H51H3	Human	E. coli	Human IL-1 beta / IL-1F2 Protein, His Tag (MALS verified)
HOT ILB-H82E9	Human	HEK293	Biotinylated Human IL-1 beta / IL-1F2 Protein, His,Avitag™ (MALS verified)
HOT ILB-M51H3	Mouse	E. coli	Mouse IL-1 beta / IL-1F2 Protein, His Tag (MALS verified)
CRS-A012	Human	-	resDetect™ Human Interleukin-1 beta (IL-1 beta) ELISA Kit (Residue Testing)
ILA-H525c	Human	HEK293	Human IL-1 beta / IL-1F2 Protein, Fc Tag (MALS verified)
ILB-H5113	Human	E. coli	Human IL-1 beta / IL-1F2 Protein, Research Grade
ILB-C51H3	Cynomolgus	E. coli	Cynomolgus IL-1 beta / IL-1F2 Protein, His Tag

총 수량10

IL-1 beta분자 배경

Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta. IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

IL-1 beta분자 별명

IL1B,IL-1BETA,IL1F2,IL-1β

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Ensereptide	PXL-01	Phase 3 Clinical	Promore Pharma	Cicatrix; Post-surgical adhesions; Tissue Adhesions	상세
Efprezimod alfa	CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110	Phase 3 Clinical	Oncoimmune Inc	Coronavirus Disease 2019 (COVID-19); Dyslipidemias; Graft vs Host Disease; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Leukemia; Leukemia, Myeloid, Acute; Melanoma; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid tumours	상세
Lutikizumab	ABT-981	Phase 3 Clinical	Abbvie Inc	Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Hidradenitis Suppurativa; Osteoarthritis; Osteoarthritis, Knee	상세
Goflikicept	RPH-104	Phase 3 Clinical	Trpharm	Arthritis, Gouty; Coronavirus Disease 2019 (COVID-19); Familial Mediterranean Fever; Gout; Pancreatitis; Pericarditis; Schnitzler Syndrome; ST Elevation Myocardial Infarction; Still's Disease, Adult-Onset	상세
KPL-387	KPL-387	Phase 3 Clinical	Kiniksa Pharmaceuticals Ltd	Heart Diseases; Pericarditis	상세
Canakinumab biosimilar (GENERIUM Pharmaceuticals)	GNR-086	Phase 3 Clinical	Generium Pharmaceuticals	Arthritis, Juvenile; Still's Disease, Adult-Onset	상세
Arumakimig	MAS825; MAS-825	Phase 3 Clinical	Novartis Pharmaceuticals Corp	Autoimmune Lymphoproliferative Syndrome; Coronary Disease; Coronavirus Disease 2019 (COVID-19); Enterocolitis; Still's Disease, Adult-Onset	상세
AVTX-009	FL-101; AVTX-009; LY-2189102	Phase 2 Clinical	Eli Lilly And Company	Arthritis, Rheumatoid; Autoimmune Diseases; Carcinoma, Non-Small-Cell Lung; Diabetes Mellitus, Type 2; Hidradenitis Suppurativa; Urinary Bladder Neoplasms	상세
CU-06	CU-06-EYE; CU-06-IBD; CU-061004; Sac-1004; CU-06-ONCO; CU-06-HAE; CU06-1004	Phase 2 Clinical	Curacle Co Ltd	Angioedemas, Hereditary; Colitis, Ulcerative; Crohn Disease; Diabetic macular oedema; Diabetic Retinopathy; Lung Diseases; Macular Degeneration; Myocardial Infarction; Neoplasms; Stroke	상세
ABBV-9832	ABBV-9832	Phase 2 Clinical	Abbvie Inc	Arthritis, Rheumatoid	상세
ABBV-166	ABBV-166	Phase 2 Clinical	Abbvie Inc	Arthritis, Psoriatic; Crohn Disease	상세
IL1-beta receptor antagonist Therapy(Hamlet BioPharma)		Phase 2 Clinical	Hamlet BioPharma AB	Cystitis; Pain	상세
Gevokizumab	XMA-005.2; AB-7; XOMA-052; S-78989; VPM-087; XMA-0052	Phase 1 Clinical	Xoma Corp	Acne Vulgaris; Arthritis, Rheumatoid; Behcet Syndrome; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Cryopyrin-Associated Periodic Syndromes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Esophageal Neoplasms; Hereditary Autoinflammatory Diseases; Labyrinth Diseases; Osteoarthritis; Panuveitis; Pyoderma Gangrenosum; Stomach Neoplasms; Uveitis	상세
GenSci-161	GenSci-161	Phase 1 Clinical	Changchun GeneScience Pharmaceuticals Co Ltd	Endometriosis; Hidradenitis Suppurativa	상세
Diacerein ointment (TWi Biotechnology)	AC-203	Phase 1 Clinical	Twi Biotechnology Inc	Epidermolysis Bullosa; Pemphigoid, Bullous	상세
DLX-2323	DLX-2323	Phase 1 Clinical	Delenex Therapeutics Ag	Inflammation	상세
Tavo-103	Tavo103; Tavo-103; TAVO-103A; TAVO103A	Phase 1 Clinical	Tavotek Biotherapeutics (Hong Kong) Ltd		상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Canakinumab	ACZ-885	Approved	Novartis Pharma Ag	Ilaris	United States	Muckle-Wells Syndrome (MWS); Cryopyrin-Associated Periodic Syndromes	Novartis Pharma Ag	2009-06-17	Alzheimer Disease; Anemia; Anemia, Sickle Cell; Aortic Aneurysm, Abdominal; Arthritis, Gouty; Arthritis, Juvenile; Arthritis, Rheumatoid; Atherosclerosis; Behcet Syndrome; Carcinoma, Non-Small-Cell Lung; Cardiovascular Diseases; Chronic Urticaria; Cognitive Dysfunction; Coronavirus Disease 2019 (COVID-19); Cryopyrin-Associated Periodic Syndromes; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Familial Mediterranean Fever; Gout; Hepatitis, Alcoholic; Hereditary Autoinflammatory Diseases; Hyperimmunoglobulin D syndrome; Inflammation; Lung Neoplasms; Mevalonate Kinase Deficiency; Muckle-Wells Syndrome (MWS); Mucocutaneous Lymph Node Syndrome; Muscular Dystrophy, Duchenne; Myelodysplastic Syndromes; Peripheral Arterial Disease; Polyarticular Juvenile Idiopathic Arthritis; Polycythemia Vera; Prediabetic State; Primary Myelofibrosis; Pulmonary Disease, Chronic Obstructive; Pyoderma Gangrenosum; Sarcoidosis, Pulmonary; Schnitzler Syndrome; Still's Disease, Adult-Onset;	상세
PG-201	PG-201	Approved	Viromed	Layla	South Korea	Osteoarthritis	Pmg Pharm Co Ltd	2012-01-01	Osteoarthritis; Osteoarthritis, Knee	상세
Edaravone/(+)-2-Decanol	SIM-071201	Approved	Jiangsu Simcere Pharmaceutical Co Ltd	三贝心, 三贝欣, 先必新, Sanbexin	Mainland China	Stroke	Nanjing Simcere Dongyuan Pharmaceutical Co Ltd	2020-07-29	Alzheimer Disease; Amyotrophic Lateral Sclerosis; Brain Infarction; Cerebral Hemorrhage; Cognition Disorders; Ischemic Stroke; Stroke	상세
Diacerein	KW-4800; SF-277; Art-50	Approved		Cartivix, Fisiodar, Verboril, Art, 安必丁, Artrodar, Artrolyt					Coronavirus Disease 2019 (COVID-19); Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Epidermolysis Bullosa; Insulin Resistance; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Overweight	상세
Firsekibart	GenSci-048; GenSci048	Approved	Changchun GeneScience Pharmaceuticals Co Ltd	金蓓欣	Mainland China	Arthritis, Gouty	Changchun GeneScience Pharmaceuticals Co Ltd	2025-06-30	Arthritis, Gouty; Arthritis, Juvenile; Arthritis, Rheumatoid; Endometriosis; Gout; Lung Diseases, Interstitial; Pain; Solid tumours; Still's Disease, Adult-Onset; systemic sclerosis-associated interstitial lung disease	상세
Metaxalone (Primus Pharmaceuticals)		Approved	Primus Pharmaceuticals Inc		United States	Muscle Spasticity	Primus Pharmaceuticals Inc	2015-06-01	Muscle Spasticity	상세
Andrographolide/Sodium Hydrogen Sulfite		Approved							Bacterial Infections	상세
Edaravone/(+)-2-Decanol (Yantai Yene/Simcere)	Y-2	Approved	Simcere Pharmaceutical Group Ltd, Yantai Yene Pharma Co Ltd		Mainland China	Stroke	Jiangsu Simcere Pharmaceutical Co Ltd	2024-12-01	Cerebral Hemorrhage; Cognitive Dysfunction; Intracranial Hemorrhages; Ischemic Stroke; Stroke	상세
Rilonacept	KPL-914; RGN-303	Approved	Regeneron Pharmaceuticals Inc	Arcalyst, 炎朵	United States	Cryopyrin-Associated Periodic Syndromes	Kiniksa Pharmaceuticals Ltd	2008-02-27	Anemia; Arthritis, Juvenile; Atherosclerosis; Coronary Artery Disease; Cryopyrin-Associated Periodic Syndromes; Deficiency of interleukin-1 receptor antagonist; Diabetes Mellitus, Type 1; Familial Mediterranean Fever; Genetic Diseases, Inborn; Gout; Hearing Loss, Sensorineural; Inflammation; Muckle-Wells Syndrome (MWS); Pericarditis; Renal Insufficiency, Chronic; Sarcoidosis; Schnitzler Syndrome; Scleroderma, Diffuse; Scleroderma, Systemic; Still's Disease, Adult-Onset; Urticaria; Vascular Diseases	상세
Thalidomide	NSC-66847; NSC-527179; K-17; FPF-300; FPF300	Approved	Celgene Corp	Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled	Mainland China	Leprosy, Lepromatous; Multiple Myeloma	Changzhou Pharmaceutical Factory	1982-01-01	Acquired Immunodeficiency Syndrome; Adenocarcinoma, Clear Cell; Adenoma, Islet Cell; Amyotrophic Lateral Sclerosis; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Anemia, Sideroblastic; Angiodysplasia; Appendiceal Neoplasms; Arachnoiditis; Arteriovenous Malformations; Axial Spondyloarthritis; beta-Thalassemia; Burning Mouth Syndrome; Carcinoid Tumor; Carcinoma, Adenosquamous; Carcinoma, Hepatocellular; Cholangitis, Sclerosing; Colorectal Neoplasms; Cough; Endometrial Neoplasms; Endometriosis; Epilepsy; Erythema Nodosum; Gastric Antral Vascular Ectasia; Gastrointestinal Hemorrhage; Genetic Diseases, Inborn; Glioma; Graft vs Host Disease; Head and Neck Neoplasms; Hemoglobinopathies; HIV Infections; HIV Wasting Syndrome; Hodgkin Disease; Hormone-Resistant Prostate Neoplasms; Hypertension, Portal; Idiopathic Pulmonary Fibrosis; Kidney Neoplasms; Leiomyosarcoma; Leprosy, Lepromatous; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelomonocytic, Chronic; Liver Neoplasms; Lung Neoplasms	상세

제품 리뷰

k***r2023-06-27
0사람들이 좋아합니다
Human IL-1β ELISA Kit
used this elisa as a control to compare against other methods of cytokine detection. quantification form both methods were similar and therefore the elisa worked well for our purpose.