Human TREM2 (19-157) Protein, Fc Tag

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제품 번호/규격
가격
수량
TR2-H5258-100ug
$380.00
TR2-H5258-1mg (500ug X 2)
$2745.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    Triggering receptor expressed on myeloid cells 2, TREM2, TREM-2

  • Source

    Human TREM2 (19-157) Protein, Fc Tag (TR2-H5258) is expressed from human 293 cells (HEK293). It contains AA His 19 - His 157 (Accession # Q9NZC2-1).

    Predicted N-terminus: His 19

    Request for sequence
  • Molecular Characterization

    TREM2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 42.1 kDa. The protein migrates as 50-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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데이터 표시

  • SDS-PAGE

    TREM2 SDS-PAGE

    Human TREM2 (19-157) Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     TREM2 ELISA

    Immobilized Human TREM2 (19-157) Protein, Fc Tag (Cat. No. TR2-H5258) at 1 μg/mL (100 μL/well) can bind Anti-TREM2 Antibody, Human IgG1 with a linear range of 1-31 ng/mL (QC tested).

    Protocol

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배경 소개

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is a pivotal cell-surface receptor primarily found on microglia in the brain and macrophages in peripheral tissues. Acting as a lipid and amyloid-beta sensor, it signals through the adapter protein DAP12 to regulate immune responses, cell survival, and phagocytosis. In neurobiology, TREM2 is a major focus because its dysfunction is strongly linked to Alzheimer’s disease progression and impaired clearance of neurotoxic plaques.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Triggering receptor expressed on myeloid cells 2

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    4 상세

  • 최고 개발 단계:

    Phase 2 Clinical

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