Human SLAMF7 / CRACC / CD319 Protein, Fc Tag

제품 번호/규격
가격
수량
SL7-H5256-100ug
$260.00
SL7-H5256-1mg
$1700.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12

  • Source

    Human SLAMF7, Fc Tag (SL7-H5256) is expressed from human 293 cells (HEK293). It contains AA Ser 23 - Met 226 (Accession # Q9NQ25).

    Predicted N-terminus: Ser 23

    Request for sequence
  • Molecular Characterization

    SLAMF7 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 49.0 kDa. The protein migrates as 60-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.1 EU per μg by the LAL method / rFC method.

  • Purity

    >85% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    SLAMF7 SDS-PAGE

    Human SLAMF7, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85%.

  • Bioactivity-ELISA

     SLAMF7 ELISA

    Immobilized Human SLAMF7, Fc Tag (Cat. No. SL7-H5256) at 1 μg/mL (100 μL/well) can bind Anti-SLAMF7/CS1 Antibody, Human IgG1 with a linear range of 0.2-2 ng/mL (QC tested).

    Protocol
  •  SLAMF7 ELISA

    Immobilized Human SLAMF7, Fc Tag (Cat. No. SL7-H5256) at 2 μg/mL (100 μL/well) can bind Humanized Anti-Human CS1 MAb with a linear range of 0.3-10 ng/mL (Routinely tested).

    Protocol
  • Bioactivity-FACS

     SLAMF7 FACS

    2e5 of SLAMF7-CAR-293 cells transfected with anti-SLAMF7-scFv were stained with 100 μL of 0.3 μg/mL of Human SLAMF7, Fc Tag (Cat. No. SL7-H5256) and negative control protein respectively, washed and then followed by PE anti-human IgG Fc antibody and analyzed with FACS (Routinely tested).

    Protocol
  •  SLAMF7 FACS

    Binding activity of two different lots of Human SLAMF7, Fc Tag against Anti-SLAMF7 CAR-293 cells was evaluated by flow cytometry. The result shows very high batch-to-batch consistency.​

    Protocol

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배경 소개

SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    SLAM family member 7

  • 카테고리:

  • 상장 의약품 수:

    1 상세

  • 임상 의약품 수:

    8 상세

  • 최고 개발 단계:

    Approved

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  • 데이터 표시
  • 사용자 리뷰
  • 배경
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