Rat Siglec-3 / CD33 Protein, His Tag (MALS verified)

사용자 리뷰
제품 번호/규격
가격
수량
CD3-R52H4-100ug
$360.00
CD3-R52H4-1mg (500ug X 2)
$2380.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    CD33, SIGLEC3, gp67

  • Source

    Rat Siglec-3, His Tag (CD3-R52H4) is expressed from human 293 cells (HEK293). It contains AA Asp 18 - Gln 240 (Accession # F1LTZ3-1).

    Predicted N-terminus: Asp 18

    Request for sequence
  • Molecular Characterization

    Siglec-3 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 26.7 kDa. The protein migrates as 37-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    Siglec-3 SDS-PAGE

    Rat Siglec-3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    Siglec-3 SEC-MALS

    The purity of Rat Siglec-3, His Tag (Cat. No. CD3-R52H4) is more than 90% and the molecular weight of this protein is around 32-47 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Siglec-3 ELISA

    Immobilized Rat Siglec-3, His Tag (Cat. No. CD3-R52H4) at 1 μg/mL (100 μL/well) can bind Anti-CD33 antibody, Mouse IgG1 with a linear range of 0.2-16 ng/mL (QC tested).

    Protocol

사용자 리뷰
댓글 남기기

배경 소개

Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig­like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cD encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-­terminal Ig-­like V­-type domain, one Ig­-like C2-­type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Myeloid cell surface antigen CD33

  • 카테고리:

  • 상장 의약품 수:

    1 상세

  • 임상 의약품 수:

    44 상세

  • 최고 개발 단계:

    Approved

연락하기
신약 후보물질 라이선싱
더 많이 알아보기
  • 기본 제품 정보
  • 제품 세부정보
  • 고객님도 확인한 상품
  • 데이터 표시
  • 사용자 리뷰
  • 배경
문의하기

전화
글로벌: +1 800-810-0816 (무료)
아시아태평양: +86 400-682-2521

주소 서울특별시 송파구 법원로11길 11, 제3층 제비-314,315호