Cynomolgus Siglec-3 / CD33 Protein, His Tag (MALS verified)

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CD3-C52H4-100ug
$360.00
In Stock - Delivery in 2-3 business days
CD3-C52H4-1mg
$2615.00
In Stock - Delivery in 2-3 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    CD33, SIGLEC3, gp67

  • Source

    Cynomolgus Siglec-3, His Tag (CD3-C52H4) is expressed from human 293 cells (HEK293). It contains AA Met 16 - Leu 228 (Accession # XP_045235686.1).

    Predicted N-terminus: Met 16

    Request for sequence
  • Molecular Characterization

    Siglec-3 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 25.7 kDa. The protein migrates as 38-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    Siglec-3 SDS-PAGE

    Cynomolgus Siglec-3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Siglec-3 SEC-MALS

    The purity of Cynomolgus Siglec-3, His Tag (Cat. No. CD3-C52H4) is more than 90% and the molecular weight of this protein is around 40-60 kDa verified by SEC-MALS.

    Report

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배경 소개

Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig­like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cD encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-­terminal Ig-­like V­-type domain, one Ig­-like C2-­type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Myeloid cell surface antigen CD33

  • 카테고리:

  • 상장 의약품 수:

    1 상세

  • 임상 의약품 수:

    44 상세

  • 최고 개발 단계:

    Approved

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