Rat Siglec-15 / CD33L3 Protein, His Tag (MALS verified)

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SG5-R52H3-100ug
$360.00
SG5-R52H3-1mg (500ug X 2)
$2615.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    CD33 antigen-like 3, SIGLEC-15, CD33L3, sialic acid-binding Ig-like lectin 15, Siglec15, Siglec-15

  • Source

    Rat Siglec-15 Protein, His Tag (SG5-R52H3) is expressed from human 293 cells (HEK293). It contains AA Arg 24 - Pro 257 (Accession # D3ZL05).

    Predicted N-terminus: Arg 24

    Request for sequence
  • Molecular Characterization

    Siglec-15 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 27.4 kDa. The protein migrates as 32-37 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a dimer.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5 M Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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데이터 표시

  • SDS-PAGE

    Siglec-15 SDS-PAGE

    Rat Siglec-15 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Siglec-15 SEC-MALS

    The purity of Rat Siglec-15 Protein, His Tag (Cat. No. SG5-R52H3) is more than 85% and the molecular weight of this protein is around 58-73 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Siglec-15 ELISA

    Immobilized Rat Siglec-15 Protein, His Tag (Cat. No. SG5-R52H3) at 1 μg/mL (100 μL/well) can bind Mouse Human chimeric mAb (5G12, Human IgG1) with a linear range of 0.06-2 ng/mL (QC tested).

    Protocol

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배경 소개

Siglec-15 is a transmembrane glycoprotein belonging to the Siglec family, recognized for its sialic acid-binding properties and role in immune regulation. Structurally, its extracellular domain contains two Ig-like domains, and it functionally associates with the signaling adaptors DAP12 and DAP10. Siglec-15 is expressed on immune cells, including osteoclasts, macrophages, and dendritic cells. It exerts its function by binding to its ligand, the sialyl-Tn antigen. This interaction is critical for inducing TGF-beta production by tumor-associated macrophages and plays an essential role in osteoclast formation and TRANCE/RANK Ligand signaling.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Sialic acid-binding Ig-like lectin 15

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    3 상세

  • 최고 개발 단계:

    Phase 2 Clinical

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