Unconjugated Human LTBR / TNFRSF3 Protein, His,Avitag™ (MALS verified)

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제품 번호/규격
가격
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LTR-H52E3-100ug
$235.00
LTR-H52E3-1mg (500ug X 2)
$1235.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    LTBR, D12S370, TNFCR, TNFR3, TNFRSF3, TNFRIII

  • Source

    Unconjugated Human LTBR Protein, His,Avitag (LTR-H52E3) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Met 227 (Accession # P36941-1).

    Predicted N-terminus: Gln 31

    Request for sequence
  • Molecular Characterization

    LTBR Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 25.3 kDa. The protein migrates as 33-35 kDa and 37-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    LTBR SDS-PAGE

    Unconjugated Human LTBR Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    LTBR SEC-MALS

    The purity of Unconjugated Human LTBR Protein, His,Avitag (Cat. No. LTR-H52E3) is more than 95% and the molecular weight of this protein is around 25-38 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     LTBR ELISA

    Immobilized Unconjugated Human LTBR Protein, His,Avitag (Cat. No. LTR-H52E3) at 5 μg/mL (100 μL/well) can bind Human LIGHT Protein, Fc Tag (Cat. No. LIT-H5269) with a linear range of 0.06-0.5 ng/mL (QC tested).

    Protocol
  •  LTBR ELISA

    Immobilized Human LIGHT Protein, Mouse IgG2a Fc Tag (Cat. No. LIT-H5256) at 5 μg/mL (100 μL/well) can bind Unconjugated Human LTBR Protein, His,Avitag (Cat. No. LTR-H52E3) with a linear range of 0.039-0.625 μg/mL (Routinely tested).

    Protocol

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배경 소개

Lymphotoxin-beta receptor (LTBR) is also known as Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), Tumor necrosis factor receptor type III (TNF-RIII), which is a single-pass type I membrane protein containing four TNFR-Cys repeat regions. Except for interacting with HCV core protein, LTBR can not only associate with itself, but also can associate with TRAF3, TRAF4 and TRAF5. As the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT, LTBR promotes apoptosis via TRAF3 and TRAF5. Furthermore, LTBR may play a role in the development of lymphoid organs.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Tumor necrosis factor receptor superfamily member 3

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    2 상세

  • 최고 개발 단계:

    Phase 1 Clinical

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