Human LGR4 / GPR48 protein, His Tag

사용자 리뷰
제품 번호/규격
가격
수량
LG4-H52H3-100ug
$360.00
LG4-H52H3-1mg (500ug X 2)
$2615.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    LGR4, GPR48, G-protein coupled receptor 48, Leucine-rich repeat-containing G-protein coupled receptor 4

  • Source

    Human LGR4, His Tag (LG4-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 25 - Thr 544 (Accession # Q9BXB1-1).

    Request for sequence
  • Molecular Characterization

    LGR4 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 58.8 kDa. The protein migrates as 70-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >85% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    LGR4 SDS-PAGE

    Human LGR4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     LGR4 ELISA

    Immobilized Human R‑Spondin 3 at 2 μg/mL (100 μL/well) can bind Human LGR4, His Tag (Cat. No. LG4-H52H3) with a linear range of 10-78 ng/mL (QC tested).

    Protocol
  • Bioactivity-SPR

     LGR4 SPR

    Human R-Spondin 3 immobilized on CM5 Chip can bind Human LGR4, His Tag (Cat. No. LG4-H52H3) with an affinity constant of 0.394 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

    Protocol

사용자 리뷰
댓글 남기기

배경 소개

The fourth member of the leucine-rich repeat-containing GPCR family (LGR4, frequently referred to as GPR48) together with its family members LGR5 and -6, bind to R-spondins (RSPOs)-1–4 and result in Wnt signaling potentiation. In addition, LGR4 (as well as LGR5 and -6) is implicated in multiple cancers and promotes invasion and metastasis in colorectal, prostate, and cervical cancer cell lines.

프론티어 진행

 
연락하기
신약 후보물질 라이선싱
더 많이 알아보기
  • 기본 제품 정보
  • 제품 세부정보
  • 고객님도 확인한 상품
  • 데이터 표시
  • 사용자 리뷰
  • 배경
문의하기

전화
글로벌: +1 800-810-0816 (무료)
아시아태평양: +86 400-682-2521

주소 서울특별시 송파구 법원로11길 11, 제3층 제비-314,315호