제품 수집
제품 세부정보
Synonyms
LAIR1, CD305
Source
Human LAIR-1, Fc Tag (LA1-H5252) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - His 163 (Accession # Q6GTX8-1).
Predicted N-terminus: Gln 22
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 42.1 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
고객님도 확인한 상품
데이터 표시
SDS-PAGE
Human LAIR-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
SEC-MALS
The purity of Human LAIR-1, Fc Tag (Cat. No. LA1-H5252) is more than 95% and the molecular weight of this protein is around 85-105 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Human Collagen I protein at 2 μg/mL (100 μL/well) can bind Human LAIR-1, Fc Tag (Cat. No. LA1-H5252) with a linear range of 0.02-0.3 μg/mL (QC tested).
Protocol
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배경 소개
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.
프론티어 진행
의약품 개발 진행- 영어 이름：
Leukocyte-associated immunoglobulin-like receptor 1
- 카테고리：
- 상장 의약품 수：
0 상세
- 임상 의약품 수：
2 상세
- 최고 개발 단계：
Phase 2 Clinical
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전화
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