Mouse LAG-3 / CD223 Protein, His Tag, low endotoxin (MALS verified)

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제품 번호/규격
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LA3-M52H5-100ug
$360.00
LA3-M52H5-1mg (100ug X 10)
$2245.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    LAG3, CD223, FDC

  • Source

    Mouse LAG-3, His Tag (LA3-M52H5) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Leu 442 (Accession # Q61790).

    Predicted N-terminus: Gly 24

    Request for sequence
  • Molecular Characterization

    LAG-3 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 47.1 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a dimer.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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데이터 표시

  • SDS-PAGE

    LAG-3 SDS-PAGE

    Mouse LAG-3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    LAG-3 SEC-MALS

    The purity of Mouse LAG-3, His Tag (Cat. No. LA3-M52H5) is more than 95% and the molecular weight of this protein is around 90-115 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     LAG-3 ELISA

    Immobilized Mouse LAG-3, His Tag (Cat. No. LA3-M52H5) at 5 μg/mL (100 μL/well) can bind Mouse FGL1, Fc Tag (Cat. No. FG1-M5258) with a linear range of 0.02-0.625 μg/mL (QC tested).

    Protocol

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배경 소개

Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Lymphocyte activation gene 3 protein

  • 카테고리:

  • 상장 의약품 수:

    1 상세

  • 임상 의약품 수:

    32 상세

  • 최고 개발 단계:

    Approved

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