Feline Insulin R / CD220 (28-956) Protein, His Tag (HPLC verified)

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제품 번호/규격
가격
수량
INR-C52H3-100ug
$360.00
INR-C52H3-1mg
$2615.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    INSR, Insulin receptor, IR, CD220

  • Source

    Feline Insulin R (28-956) Protein, His Tag (INR-C52H3) is expressed from human 293 cells (HEK293). It contains AA His 28 - Ile 956 (Accession # A0A2I2UE37).

    Predicted N-terminus: His 28

    Request for sequence
  • Molecular Characterization

    Insulin R Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 107.5 kDa. The protein migrates as 35-48 kDa and 110-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-HPLC.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    Insulin R SDS-PAGE

    Feline Insulin R (28-956) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-HPLC

    Insulin R SEC-HPLC

    The purity of Feline Insulin R (28-956) Protein, His Tag (Cat. No. INR-C52H3) was greater than 95% as determined by SEC-HPLC.

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배경 소개

Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Insulin receptor

  • 카테고리:

  • 상장 의약품 수:

    97 상세

  • 임상 의약품 수:

    114 상세

  • 최고 개발 단계:

    Approved

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