Mouse IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag

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ILR-M5257-100ug
$400.00
In Stock - Delivery in 2-3 business days
ILR-M5257-1mg (500ug X 2)
$2600.00
In Stock - Delivery in 2 weeks
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    IL7Ra, CD127, TSLP R, CRLF2, IL-XR, ILXR, p2RY8, CRLF2 fusion, TSLP receptor, TSLPR, CRL2, CRLF2Y, Cytokine receptor-like 2

  • Source

    Mouse IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (ILR-M5257) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Asp 239 (IL-7 RA) & Ala 20 - Pro 232 (TSLP R) (Accession # P16872 (IL-7 RA) & Q8CII9 (TSLP R)).

    Predicted N-terminus: Glu 21 (IL-7 RA) & Ala 20 (TSLP R)

    Request for sequence
  • Molecular Characterization

    IL-7 R alpha & TSLP R Structure

    Other Tags and Version Biotin & Other Labeled Version

    Mouse IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag is produced by co-expression of IL-7 RA and TSLP R, has a calculated MW of 51.5 kDa (IL-7 RA) & 48.8 kDa (TSLP R). Subunit IL-7 RA is fused with a human IgG1 Fc fragment at the C-terminus and subunit TSLP R is fused with a human IgG1 Fc fragment at the C-terminus. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.1 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    IL-7 R alpha & TSLP R SDS-PAGE

    Mouse IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     IL-7 R alpha & TSLP R ELISA

    Immobilized Mouse TSLP, His Tag (Cat. No. TSP-M52H8) at 5 μg/mL (100 μL/well) can bind Mouse IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-M5257) with a linear range of 0.2-5 ng/mL (QC tested).

    Protocol
  •  IL-7 R alpha & TSLP R ELISA

    Immobilized Biotinylated Mouse TSLP, His,Avitag (Cat. No. TSP-M82E3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Mouse IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag (Cat. No. ILR-M5257) with a linear range of 0.2-2 ng/mL (Routinely tested).

    Protocol

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배경 소개

TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Mouse TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Interleukin-7 receptor subunit alpha

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    8 상세

  • 최고 개발 단계:

    Phase 2 Clinical

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