Cynomolgus IL-3 R alpha / CD123 Protein, His Tag (SPR verified)

사용자 리뷰
제품 번호/규격
가격
수량
ILA-C52H6-100ug
$360.00
ILA-C52H6-1mg
$2615.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    IL3R, IL3RA, IL-3Ra, IL-3R-alpha, IL3RAY, IL3RX, IL3RY, CD123 antigen, CD123, hIL3Ra, hIL-3Ra, MGC34174, IL-3 R alpha

  • Source

    Cynomolgus IL-3 R alpha Protein, His Tag (ILA-C52H6) is expressed from human 293 cells (HEK293). It contains AA Arg 18 - Arg 302 (Accession # G8F3K3-1).

    Predicted N-terminus: Arg 18

    Request for sequence
  • Molecular Characterization

    IL-3 R alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 34.7 kDa. The protein migrates as 47-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    IL-3 R alpha SDS-PAGE

    Cynomolgus IL-3 R alpha Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-SPR

     IL-3 R alpha SPR

    Cynomolgus IL-3 R alpha Protein, His Tag (Cat. No. ILA-C52H6) captured on CM5 Chip via anti-His antibody can bind Human IL-3, Tag Free with an affinity constant of 0.271 μM as determined in SPR assay (Biacore 8k) (QC tested).

    Protocol
  • Bioactivity-BLI

     IL-3 R alpha BLI

    Loaded Cynomolgus IL-3 R alpha Protein, His Tag (Cat. No. ILA-C52H6) on NTA Biosensor, can bind Human IL-3, Tag Free with an affinity constant of 0.4 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

    Protocol

사용자 리뷰
댓글 남기기

배경 소개

Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Interleukin-3 receptor subunit alpha

  • 카테고리:

  • 상장 의약품 수:

    1 상세

  • 임상 의약품 수:

    40 상세

  • 최고 개발 단계:

    Approved

연락하기
신약 후보물질 라이선싱
더 많이 알아보기
  • 기본 제품 정보
  • 제품 세부정보
  • 고객님도 확인한 상품
  • 데이터 표시
  • 사용자 리뷰
  • 배경
문의하기

전화
글로벌: +1 800-810-0816 (무료)
아시아태평양: +86 400-682-2521

주소 서울특별시 송파구 법원로11길 11, 제3층 제비-314,315호