Mouse IL-17A&IL-17F Heterodimer Protein, His Tag (MALS verified)

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ILF-M52H3-100ug
$550.00
In Stock - Delivery in 2-3 business days
ILF-M52H3-1mg (500ug X 2)
$2500.00
In Stock - Delivery in 2 weeks
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    IL-17A, Interleukin-17A, CTLA-8, IL-17, IL-17F, Interleukin-17F, Cytokine ML-1, IL17A&IL17F

  • Source

    Mouse IL-17A&IL-17F Heterodimer Protein, His Tag (ILF-M52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Ala 158 & Arg 29 - Ala 161 (Accession # Q62386 & Q7TNI7).

    Predicted N-terminus: Ala 26 & Arg 29

    Request for sequence
  • Molecular Characterization

    IL-17A & IL-17F Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 38.7 kDa. The protein migrates as 38-46 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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데이터 표시

  • SDS-PAGE

    IL-17A & IL-17F SDS-PAGE

    Mouse IL-17A&IL-17F Heterodimer Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-17A & IL-17F SEC-MALS

    The purity of Mouse IL-17A&IL-17F Heterodimer Protein, His Tag (Cat. No. ILF-M52H3) is more than 90% and the molecular weight of this protein is around 35-55 kDa verified by SEC-MALS.

    Report

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배경 소개

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Interleukin-17F

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    5 상세

  • 최고 개발 단계:

    NDA/BLA

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