Human IL-13 Protein, GST Tag

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제품 번호/규격
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IL3-H52G3-50ug
$400.00
IL3-H52G3-500ug
$2040.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    IL13, ALRH, BHR1, MGC116786, MGC116788, MGC116789, P600, Interleukin-13

  • Source

    Human IL-13 Protein, GST Tag (IL3-H52G3) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Asn 132 (Accession # AAK53823.1).

    Predicted N-terminus: Gly 21

    Request for sequence
  • Molecular Characterization

    IL-13 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a GST tag at the C-terminus.

    The protein has a calculated MW of 38.5 kDa. The protein migrates as 48-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    IL-13 SDS-PAGE

    Human IL-13 Protein, GST Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • Bioactivity-ELISA

     IL-13 ELISA

    Immobilized Human IL-13 Protein, GST Tag (Cat. No. IL3-H52G3) at 5 μg/mL (100 μL/well) can bind Human IL-13 R alpha 2 Protein, Fc Tag (Cat. No. IL2-H5256) with a linear range of 0.3-10 ng/mL (QC tested).

    Protocol
  • Bioactivity-SPR

     IL-13 SPR

    Monoclonal Anti-Human IL-13 Antibody, Human IgG4 captured on Protein A Chip can bind Human IL-13 Protein, GST Tag (Cat. No. IL3-H52G3) with an affinity constant of 2.03 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

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배경 소개

Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Interleukin-13

  • 카테고리:

  • 상장 의약품 수:

    4 상세

  • 임상 의약품 수:

    27 상세

  • 최고 개발 단계:

    Approved

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