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Human IFN-alpha / beta R1 (228-436) Protein, His Tag, low Endotoxin (MALS verified)

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IF1-H52H4-100ug
$380.00
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IF1-H52H4-1mg (500ug X 2)
$2,615.00
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IF1-H52H4
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

IFNAR1, IFNAR, CRF2-1, IFN-R-1, IFNAR-1

Source

Human IFN-alpha / beta R1 (228-436) Protein, His Tag (IF1-H52H4) is expressed from human 293 cells (HEK293). It contains AA Glu 228 - Lys 436 (Accession # P17181-1).

Predicted N-terminus: Glu 228

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 26.1 kDa. The protein migrates as 35-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 0.01 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Interferon alpha/beta receptor 1 ( IFR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFR, which belongs to the type II cytokine receptor family. IFR1 /IFR contains four fibronectin type-III domains. IFR1 associates with IFR2 to form the type I interferon receptor. IFR1 is receptor for interferons alpha and beta. IFR1 can transduce IFNB signals without the help of IFR2, and not activating the Jak-STAT pathway.