Aspergillus fumigatus Dihydroorotate Dehydrogenase Protein, His Tag

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DDE-A51H3-200ug
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DDE-A51H3-1mg
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DDE-A51H3
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Synonyms

Dihydroorotate Dehydrogenase

Source

Aspergillus fumigatus Dihydroorotate Dehydrogenase Protein, His Tag (DDE-A51H3) is expressed from E. coli cells. It contains AA Ala 89 - Gln 531 (Accession # A0A229W7A4).

Predicted N-terminus: Met

Molecular Characterization

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 49.5 kDa. The protein migrates as 55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Purity

>90% as determined by SDS-PAGE.

Formulation

Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.

배경 소개

Aspergillus fumigatus dihydroorotate dehydrogenase (DHODH) is an essential mitochondrial enzyme in the de novo pyrimidine biosynthesis pathway, required for fungal DNA and RNA synthesis. Because A. fumigatus relies on DHODH for growth and survival, the enzyme has emerged as a validated antifungal drug target, exemplified by inhibitors such as olorofim