Cynomolgus CD79A & CD79B Protein, His Tag&Flag Tag, low endotoxin (MALS verified)

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CDB-C52D3-100ug
$470.00
CDB-C52D3-1mg (500ug X 2)
$3805.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    CD79A&CD79B, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain

  • Source

    Cynomolgus CD79A & CD79B Protein, His Tag&Flag Tag (CDB-C52D3) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Arg 142 (CD79A) & Ala 30 - Asp 161 (CD79B) (Accession # XP_045235481.1 (CD79A) & A0A2K5WTH8-1 (CD79B)).

    Predicted N-terminus: Leu 33 (CD79A) & Ala 30 (CD79B)

    Request for sequence
  • Molecular Characterization

    CD79A & CD79B Structure

    Other Tags and Version Biotin & Other Labeled Version

    The protein has a calculated MW of 17.6 kDa (CD79A) & 20.1 kDa (CD79B). The protein migrates as 27-30 kDa and 33-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a heterodimer.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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데이터 표시

  • SDS-PAGE

    CD79A & CD79B SDS-PAGE

    Cynomolgus CD79A & CD79B Protein, His Tag&Flag Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD79A & CD79B SEC-MALS

    The purity of Cynomolgus CD79A & CD79B Protein, His Tag&Flag Tag (Cat. No. CDB-C52D3) is more than 95% and the molecular weight of this protein is around 40-65 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CD79A & CD79B ELISA

    Immobilized Cynomolgus CD79A & CD79B Protein, His Tag&Flag Tag (Cat. No. CDB-C52D3) at 1 μg/mL (100 μL/well) can bind Anti-cyno CD79b with a linear range of 0.02-2 ng/mL (QC tested).

    Protocol

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배경 소개

CD79a and CD79b heterodimers are the important signaling components of B cell receptor (BCR) complex which plays a crucial role in B cell development and antibody production. BCR complexes are composed of a ligand-binding receptor (membrane immunoglobulin; mIg), non-covalently associated with the signaling com-ponent, a disulfide-linked heterodimer of CD79a (Igα) and CD79b (Igβ). Both CD79 subunits consist of an Ig-like domain, a transmembrane (TM) region, and a longer cytoplasmic tail (CYT) containing an immune-receptor tyrosine-based activation motif (ITAM).

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    B-cell antigen receptor complex-associated protein alpha chain

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    0 상세

  • 최고 개발 단계:

    Preclinical

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