Biotinylated Human CD6 / TP120 Protein, Fc,Avitag™ (MALS verified)

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Cat. No. / Size
Price
Qty
CD6-H82F3-25ug
$360.00
CD6-H82F3-200ug
$1565.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    CD6, TP120, T12

  • Source

    Biotinylated Human CD6 Protein, Fc,Avitag (CD6-H82F3) is expressed from human 293 cells (HEK293). It contains AA His 18 - Glu 398 (Accession # P30203-1).

    Predicted N-terminus: His 18

    Request for sequence
  • Molecular Characterization

    CD6 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 68.7 kDa. The protein migrates as 90-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CD6 SDS-PAGE

    Biotinylated Human CD6 Protein, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD6 SEC-MALS

    The purity of Biotinylated Human CD6 Protein, Fc,Avitag (Cat. No. CD6-H82F3) is more than 90% and the molecular weight of this protein is around 185-220 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CD6 ELISA

    Immobilized Human ALCAM, His Tag (Cat. No. CD6-H5228) at 5 μg/mL (100 μL/well) can bind Biotinylated Human CD6 Protein, Fc,Avitag (Cat. No. CD6-H82F3) with a linear range of 0.01-0.313 μg/mL (QC tested).

    Protocol

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Background

CD6 is a type 1 transmembrane glycoprotein with three extracellular SRCR domains that functions as a co-stimulatory receptor in T cell activation. Its primary ligand is CD166 (ALCAM), an IgSF member expressed on antigen-presenting cells and other tissues. CD6's long cytoplasmic tail contains tyrosine residues that, upon phosphorylation, recruit signaling molecules like SLP76 and SHP1. The CD6-ALCAM interaction promotes T cell activation and downstream MAPK signaling, influencing proliferation, differentiation, and survival. Importantly, CD6 regulates effector T cell (Teff) activity and trafficking, making it a key checkpoint in autoimmunity. Blocking the CD6-ALCAM pathway selectively inhibits pathogenic Teff cells while preserving Treg function, offering a potential therapeutic strategy for autoimmune diseases.

Recent Advances

 
Drug Development Progress
  • English Name:

    T-cell differentiation antigen CD6

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    0 Details

  • Highest Development Stage:

    Approved

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