Human IL-3 R Beta / CD131 Protein, His Tag (MALS verified)

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CD1-H52H8-100ug
$360.00
CD1-H52H8-1mg
$2380.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    IL-3 R Beta, CD131, Common beta Chain

  • Source

    Human CD131 Protein, His Tag (CD1-H52H8) is expressed from human 293 cells (HEK293). It contains AA Trp 17 - Trp 443 (Accession # P32927-1).

    Predicted N-terminus: Trp 17

    Request for sequence
  • Molecular Characterization

    CD131 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 50.6 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a dimer.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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데이터 표시

  • SDS-PAGE

    CD131 SDS-PAGE

    Human CD131 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD131 SEC-MALS

    The purity of Human CD131 Protein, His Tag (Cat. No. CD1-H52H8) is more than 90% and the molecular weight of this protein is around 100-125 kDa verified by SEC-MALS.

    Report

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배경 소개

CD131- the common β Subunit, is a member of the type 1 cytokine receptor family. There are three major classes of heteroreceptor complexes, where the receptor complex utilises a common shared receptor subunit as a signal-transducing chain along with a cytokine specific subunit. These three classes include those which use gp130, those which use γc and those which use the common β subunit, βc(CD131). CD131 is shared by three of the “four-helical bundle” family of cytokines; IL-3, IL-5 and GM-CSF, and forms a receptor complex along with a cytokine specific α chain for each of these cytokines.Moreover, even though each of these cytokines have their own specific α subunit, the co-utilisation of CD131 suggests a common intra-cellular process of both unique and/or overlapping activities on expressing cells.

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