Human Activin A / INHBA Superior Active Mutant Protein, premium grade

Our Recombinant Human Activin A Superior Active Mutant Protein, developed via an AI-modified and experimentally validated closed-loop efficient protein design platform, is the optimal Activin A mutant with superior bioactivity (2 times higher) compared to wild-type Activin A. It highly facilitates stem cell differentiation into definitive endoderm lineages, including pancreatic beta islet cells and other related cell types. This enables more efficient and stable differentiation outcomes with reduced reagent consumption, significantly lowering costs while enhancing process reliability. The product provides strong support for optimizing islet differentiation and downstream cell therapy applications, offering a powerful solution for scalable and cost-effective stem cell-based production.

It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.

• Engineered via a Closed-Loop AI Design Platform – Enables rational sequence optimization to achieve maximal functional performance.
• Superior Bioactivity (2× Higher than WT Activin A) – Delivers stronger signaling for more potent and rapid differentiation initiation.
• Enables Efficient & Consistent Endoderm Differentiation – Reduces reagent usage, lowers overall costs, and accelerates the generation of functional lineages such as pancreatic beta islet cells.

Activin A, INHBA

Less than 0.05 EU per μg by the LAL method / rFC method.

<0.5 ng/µg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Negative

Negative

>95% as determined by SDS-PAGE.

>95% as determined by SEC-HPLC.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 12 months in lyophilized state;
• -70°C for 3 months under sterile conditions after reconstitution.