Monoclonal Anti-Rabies virus (strain CVS-11) Nucleoprotein Antibody, Mouse IgG1 (7B7) (MALS verified)

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Cat. No. / Size
Price
Qty
NUN-MY2301-100ug
$399.00
NUN-MY2301-1mg (500ug X 2)
$2625.00
ETA of in-stock products:2 business days

Product Details

  • Source

    Monoclonal Anti-Rabies virus (strain CVS-11) Nucleoprotein Antibody, Mouse IgG1 (7B7) is a mouse monoclonal antibody recombinantly expressed in HEK293 cells.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    7B7

  • Isotype

    Mouse IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Virus

  • Immunogen

    Recombinant Rabies virus (strain CVS-11) Nucleoprotein is expressed from Baculovirus-Insect cells

  • Specificity

    Specifically recognizes Rabies virus (strain CVS-11) Nucleoprotein.

  • Purification

    Protein A purified / Protein G purified.

  • Aggregation

    Less than 10%, as determined by SEC-MALS.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     Nucleoprotein ELISA

    Immobilized Rabies virus (strain CVS-11) Nucleoprotein, His Tag (Cat. No. NUN-R55H4) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Rabies virus (strain CVS-11) Nucleoprotein Antibody, Mouse IgG1 (7B7) (Cat. No. NUN-MY2301) with a linear range of 0.06-1 ng/mL (QC tested).

    Protocol
  •  Nucleoprotein ELISA

    Immobilized Rabies virus (strain ERA) Nucleoprotein, His Tag (Cat. No. NUN-R55H3) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Rabies virus (strain CVS-11) Nucleoprotein Antibody, Mouse IgG1 (7B7) (Cat. No. NUN-MY2301) with a linear range of 0.008-0.5 μg/mL (Routinely tested).

    Protocol

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Background

Rabies virus (RABV), scientific name Rabies lyssavirus, is a deadly neurotropic virus that causes rabies in humans and animals. Rabies virus has an extremely wide host range and its transmission most often occur through the saliva of animals. Without intervention prior to disease progression, rabies has the highest case fatality of any infectious disease. RABV contains a single-stranded negative-sense RNA genome that encodes five structural proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and RNA-dependent RNA polymerase (L). RABV N protein is 450 amino acids long and serves the critical function of tightly packaging the RNA genome into an RNase-resistant core. Encapsidation of the genomic RNA by newly synthesized N is believed to switch viral RNA from transcription to replication. Furthermore, N is a major antigen for RABV to stimulate Th cells and antibody production.

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