Biotinylated Anti-Human CD3 Antibody, Mouse F(ab')2, His,Avitag™ (Clone: OKT3), premium grade

사용자 리뷰
제품 번호/규격
가격
수량
CDE-CV81G0-50ug
$90.00
CDE-CV81G0-500ug
$300.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Source

    Biotinylated Anti-Human CD3 Antibody, Mouse F(ab')2, His,Avitag (Clone: OKT3), premium grade (CDE-CV81G0) is an F(ab')2 fragment-only antibody recombinantly expressed from HEK293 cells.

    It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.

  • Conjugate

    Biotin

  • Specificity

    This product is a specific antibody specifically reacts with CD3 epsilon.

  • Endotoxin

    Less than 0.002 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-HPLC.

  • Sterility

    Negative

  • Mycoplasma

    Negative

  • Formulation

    Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    For long term storage, the product should be stored at liquid state at -70°C.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -70°C for 12 months.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    CD3 SDS-PAGE

    Biotinylated Anti-Human CD3 Antibody, Mouse F(ab')2, His,Avitag (Clone: OKT3), premium grade on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-HPLC

    CD3 SEC-HPLC

    The purity of Biotinylated Anti-Human CD3 Antibody, Mouse F(ab')2, His,Avitag (Clone: OKT3), premium grade (Cat. No. CDE-CV81G0) was greater than 95% as determined by SEC-HPLC.

  • Bioactivity-FACS

     CD3 FACS

    Flow cytometric analysis of Human peripheral blood lymphocytes respectively staining Biotinylated Anti-Human CD3 Antibody, Mouse F(ab')2, His,Avitag (Clone: OKT3), premium grade (Cat. No. CDE-CV81G0) at 0.1 µg/mL (0.01 µg corresponds to labeling of 1e6 cells in a final volume of 100 µL) and PE Streptavidin. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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배경 소개

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    T cell surface glycoprotein CD3

  • 카테고리:

  • 상장 의약품 수:

    10 상세

  • 임상 의약품 수:

    198 상세

  • 최고 개발 단계:

    Approved

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  • 사용자 리뷰
  • 배경
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주소 서울특별시 송파구 법원로11길 11, 제3층 제비-314,315호