Select Language

ZNRF3

ZNRF3 Overview

English Name	E3 ubiquitin-protein ligase ZNRF3	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym
Highest Development Stage	Phase 1 Clinical

English Name	E3 ubiquitin-protein ligase ZNRF3
Target Synonym
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 1 Clinical

ZNRF3 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
ZN3-H52H3	Human	HEK293	Human ZNRF3 protein, His Tag (MALS verified)

Total: 1

ZNRF3 Background

The transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is a negative feedback regulator of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 and acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway.