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VSIG4

VSIG4 Overview

English Name	V-set and immunoglobulin domain-containing protein 4	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	Protein Z39Ig，CRIg，Z39IG
Highest Development Stage	Phase 1 Clinical

English Name	V-set and immunoglobulin domain-containing protein 4
Target Synonym	Protein Z39Ig，CRIg，Z39IG
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 1 Clinical

VSIG4 Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (2)
Tag
His Tag (1)His Tag & Avi Tag (1)
Conjugate
Unconjugated (1)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
VS4-H5226	Human	HEK293	Human VSIG4 Protein, His Tag
VS4-H82E3	Human	HEK293	Biotinylated Human VSIG4 Protein, His,Avitag™ (MALS verified)

Total: 2

VSIG4 Background

V-set and immunoglobulin domain-containing protein 4 (VSIG4) is also known as Protein Z39Ig, is a type I transmembrane glycoprotein. VSIG4 is a B7 family-related protein and an Ig superfamily member. VSIG4 contains two Ig-like (immunoglobulin-like) domains. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production.