언어 선택

VEGF R2

VEGF R2 분자 정보

영어 이름	Vascular endothelial growth factor receptor 2	시판 약물 수	18
임상 약물 수	61	표적 별명	EC:2.7.10.1，EC 2.7.10，VEGFR2，KDR，Vascular endothelial growth factor receptor 2，Fetal liver kinase 1，Kinase insert domain receptor，Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase)，Protein-Tyrosine Kinase Receptor Flk-1，FLK1，Tyrosine Kinase Growth Factor Receptor，Fetal Liver Kinase-1，Soluble VEGFR2，CD309 Antigen，EC 2.7.10.1，VEGFR-2，CD309，VEGFR，FLK-1，Vascular Endothelial Growth Factor Receptor-2
최고 연구 개발 단계	Approved

영어 이름	Vascular endothelial growth factor receptor 2
표적 별명	EC:2.7.10.1，EC 2.7.10，VEGFR2，KDR，Vascular endothelial growth factor receptor 2，Fetal liver kinase 1，Kinase insert domain receptor，Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase)，Protein-Tyrosine Kinase Receptor Flk-1，FLK1，Tyrosine Kinase Growth Factor Receptor，Fetal Liver Kinase-1，Soluble VEGFR2，CD309 Antigen，EC 2.7.10.1，VEGFR-2，CD309，VEGFR，FLK-1，Vascular Endothelial Growth Factor Receptor-2
시판 약물 수	18
임상 약물 수	61
최고 연구 개발 단계	Approved

VEGF R2 제품 목록

속성
Protein (9)Cell (1)
제품 라이브러리
온라인 (10)
종
Human (7)Rhesus macaque (1)Mouse (2)
태그
His Tag (4)Strep Tag (1)His Tag & Avi Tag (2)Mouse IgG Fc Tag (1)Fc Tag (1)- (1)
마커
Unconjugated (5)Biotin-labeled (2)- (1)PE Labeled (1)APC Labeled (1)

제품 번호	종	발현 시스템	제품 설명
HOT CHEK-ATF044	Human	HEK293	Human VEGF R2 (Luc) HEK293 Reporter Cell
HOT KDR-H5227	Human	HEK293	Human VEGF R2 / KDR Protein, His Tag, low endotoxin (MALS verified)
HOT KDR-H82E5	Human	HEK293	Biotinylated Human VEGF R2 / KDR Protein, Avitag™,His Tag
HOT VE2-H5255	Human	HEK293	Human VEGF R2 / KDR Protein, Fc Tag (MALS verified)
KDR-H5280	Human	HEK293	Human VEGF R2 / KDR Protein, Twin-Strep Tag (MALS verified)
KDR-HP227	Human	HEK293	PE-Labeled Human VEGF R2 / KDR Protein, His Tag (Site-specific conjugation)
VE2-HA224	Human	HEK293	APC-Labeled Human VEGF R2 / KDR Protein, His Tag (Site-specific conjugation)
VE2-M5258	Mouse	HEK293	Mouse VEGF R2 / KDR Protein, Mouse IgG2a Fc Tag, low endotoxin
VE2-M82E3	Mouse	HEK293	Biotinylated Mouse VEGF R2 / KDR Protein, His,Avitag™ (MALS verified)
VE2-C52H3	Rhesus macaque	HEK293	Rhesus macaque VEGF R2 / KDR Protein, His Tag

총 수량10

VEGF R2분자 배경

Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.

VEGF R2분자 별명

KDR,CD309,FLK1,VEGFR,VEGFR2

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Simmitinib hydrochloride	SOMCL-15-290	Phase 3 Clinical	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Breast Neoplasms; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gastroesophageal Junction Neoplasms; Neoplasms; Solid tumours; Stomach Neoplasms	상세
Inlecitug		Phase 3 Clinical	Changchun GeneScience Pharmaceuticals Co Ltd	Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Solid tumours; Stomach Neoplasms	상세
BC-001	BC001; BC-001	Phase 3 Clinical	Shandong Buchang Pharmaceuticals Co Ltd	Colorectal Neoplasms; Gastroesophageal Junction Neoplasms; Solid tumours; Stomach Neoplasms	상세
XY-0206	XY-0206	Phase 3 Clinical	Nanjing University Of Chinese Medicine	Leukemia, Myeloid, Acute; Solid tumours	상세
KC1036	KC1036; KC-1036	Phase 3 Clinical	Beijing Konruns Pharmaceutical Co Ltd	Adenocarcinoma; Digestive System Neoplasms; Esophageal Squamous Cell Carcinoma; Hematologic Neoplasms; Neoplasm Metastasis; Sarcoma, Ewing; Solid tumours; Thymus Neoplasms	상세
Cediranib	AZD2171; AZD-2171; NSC-732208	Phase 3 Clinical	Astrazeneca Plc	Adenocarcinoma; Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenocarcinoma, Mucinous; Angioimmunoblastic T-cell Lymphoma; Ascites; Astrocytoma; Bile Duct Neoplasms; Biliary Tract Neoplasms; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Burkitt Lymphoma; Carcinoma; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Carcinosarcoma; Cholangiocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Cystadenocarcinoma, Mucinous; Cystadenocarcinoma, Serous; Endometrial Neoplasms; Ependymoma; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Glioma; Gliosarcoma; Head and Neck Neoplasms; Hepatic Insufficiency; Hodgkin Disease; Hormone-Resistant Prostate Neoplasms; Hypopharyngeal Neoplasms; Intraocular Lymphoma; L	상세
Sitravatinib	MG-516; MG-91516; MGCD-516; IND-155305; MGCD-0516	Phase 3 Clinical	Mirati Therapeutics Inc	Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Gastrointestinal Neoplasms; Hepatic Insufficiency; Kidney Neoplasms; Liposarcoma; Lung Diseases; Lung Neoplasms; Metastatic breast cancer; Neoplasms; Oral Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Ureteral Neoplasms; Uterine Cervical Neoplasms; Uveal melanoma	상세
Simmitinib	SYHA-1817	Phase 3 Clinical	CSPC Pharmaceutical Group Ltd	Biliary Tract Neoplasms; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Stomach Neoplasms	상세
Axitinib intravitreal implant (Ocular Therapeutix)	OTX-TKI	Phase 3 Clinical	Ocular Therapeutix Inc	Diabetic Retinopathy; Macular Degeneration; Wet Macular Degeneration	상세
Pulocimab	AK-109; AK109	Phase 3 Clinical		Adenocarcinoma; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Solid tumours; Stomach Neoplasms	상세
Ningetinib Tosylate	CT-053-PTSA; CT-053	Phase 2 Clinical	Hec Pharm Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Intestinal Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Solid tumours; Stomach Neoplasms	상세
Recombinant Anti-VEGFR2 Fully Human Monoclonal Antibody(Jingyitaixiang Technology Development)	JY-025	Phase 2 Clinical	Beijing Eastern Biotech Co Ltd, Beijing Jingyitaixiang Technology Development Co Ltd	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Liver Neoplasms; Solid tumours; Stomach Neoplasms	상세
MSB-0254	MSB-0254	Phase 2 Clinical	Suzhou Transcenta Therapeutics Co Ltd	Solid tumours	상세
AUR-109	ODM-203; AUR-109	Phase 2 Clinical	Orion Corp	Breast Neoplasms; Carcinoma, Renal Cell; Colorectal Neoplasms; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Ovarian Neoplasms; Pulmonary Fibrosis; Solid tumours; Urinary Bladder Neoplasms	상세
(-)-Epigallocatechin gallate	AB-4166	Phase 2 Clinical	Charite Universitaetsmedizin Berlin	Alzheimer Disease; Colonic Neoplasms; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Frailty; Glaucoma, Open-Angle; Huntington Disease; Hypertension; Idiopathic Pulmonary Fibrosis; Inflammation; Insulin Resistance; Leukemia; Liver Cirrhosis; Lung Diseases, Interstitial; Multiple Sclerosis, Relapsing-Remitting; Muscular Dystrophy, Duchenne; Neoplasms; Obesity; Ocular Hypertension; Papillomavirus Infections; Parkinson Disease; Peripheral Nervous System Diseases; Prostatic Neoplasms; Uterine Cervical Diseases	상세
Lucitanib	S-80881; AL-3810; CO-3810; E-3810; S-80881-2	Phase 2 Clinical	Advenchen Laboratories Nanjing Ltd	Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Genital Neoplasms, Female; Lung Neoplasms; Metastatic breast cancer; Nasopharyngeal Carcinoma; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Thymus Neoplasms	상세
VEGFR2 peptide vaccine (VAXIMM)	VXM-01	Phase 2 Clinical	Merck Serono	Colorectal Neoplasms; Glioblastoma; Pancreatic Neoplasms	상세
Telatinib	EOC-315; BAY-57-9352	Phase 2 Clinical	Bayer AG	Solid tumours; Stomach Neoplasms	상세
Derazantinib	ARQ-087.2HCl; AQ-14741087; ARQ-087; BAL-087	Phase 2 Clinical	Arqule Inc	Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Transitional Cell; Cholangiocarcinoma; Solid tumours; Stomach Neoplasms; Urogenital Neoplasms	상세
OT-202	OT 202; OT-202	Phase 2 Clinical	Ocumension (Hong Kong) Ltd	Xerophthalmia	상세
OTP-01	OTP-01	Phase 2 Clinical	Ottimo Pharma Ltd	Neoplasms; Solid tumours	상세
Inhaled Nintedanib – dry powder (Avalyn Pharma)	AP02; AP 02 DP; AP-02; AP02-DP	Phase 2 Clinical	Avalyn Pharma Inc	Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis; Respiratory Tract Diseases	상세
BR-55	BR-55; BR55 CEUS	Phase 2 Clinical	Sonus Pharmaceuticals Ltd	Contrast agents; Diagnostic agents; Inflammation; Neoplasms; Ovarian Neoplasms	상세
Axitinib Implant（Aerie）	AR-14034 SR; AR-14034	Phase 2 Clinical	Aerie Pharmaceuticals Inc	Macular Degeneration	상세
K-13		Phase 2 Clinical	Shanghai Yifeng Biotechnology Co Ltd	Neoplasms; Solid tumours	상세
Sorafenib Tosylate/Comekibart	MG-D-1609	Phase 2 Clinical	Metagone Biotech Inc	Solid tumours	상세
Tosposertib phosphate	TU-2218; NCE401; NCE-401	Phase 2 Clinical	TiumBio Co Ltd	Idiopathic Pulmonary Fibrosis; Solid tumours	상세
VEGFR-1/2 peptide vaccine (Keio University)		Phase 2 Clinical	Keio University	Brain Neoplasms; Glioma; Neurofibromatoses	상세
Gersizangitide	AXT-107	Phase 2 Clinical	AsclepiX Therapeutics Inc	Diabetic macular oedema; Macular Degeneration	상세
KDR2-2		Phase 2 Clinical	Guangzhou Huiborui Biomedical Technology Co Ltd	Corneal Neovascularization; Glaucoma, Neovascular; Neovascularization, Pathologic	상세
KHK-4951		Phase 2 Clinical	Kyowa Kirin	Diabetic macular oedema; Macular Degeneration; Macular Edema; Wet Macular Degeneration	상세
CEP-11981	ESK-981; CEP-11981; SSR-106462; BOL-303213X	Phase 2 Clinical	Sanofi	Adenoma, Islet Cell; Bone metastases; Carcinoma, Adenosquamous; Carcinoma, Neuroendocrine; Gastrointestinal Neoplasms; Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant	상세
Axitinib injectable suspension (Clearside Biomedical)	CLS-1002; CLS-011-A; CLS011A; CLS-AX	Phase 2 Clinical	Clearside Biomedical Inc	Macular Degeneration	상세
Hydroxychloroquine/Sorafenib		Phase 2 Clinical	Vg Life Sciences	Ovarian Neoplasms; Solid tumours	상세
EDP317	ACTB-1003; EOC-317; EDP-317	Phase 1 Clinical	Act Biotech Inc, Bayer AG	Biliary Tract Neoplasms; Breast Neoplasms; Solid tumours; Stomach Neoplasms; Urinary Bladder Neoplasms	상세
Kanitinib	CX-1003	Phase 1 Clinical	Beijing Konruns Pharmaceutical Co Ltd, Guangzhou Yingsheng Bio Technology Co Ltd	Solid tumours	상세
VEGFR2 peptide vaccine (Tokyo University)		Phase 1 Clinical	University Of Tokyo	Pancreatic Neoplasms	상세
Brivanib Alaninate	ZL-2301; BMS-540215; BMS-582664	Phase 1 Clinical	Bristol-Myers Squibb Company	Adenocarcinoma, Clear Cell; Asthma; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Gastrointestinal Neoplasms; Liver Neoplasms; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Sarcoma; Solid tumours; Uterine Cervical Neoplasms	상세
Ramucirumab biosimilar (Henlius)	HLX-12	Phase 1 Clinical		Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Stomach Neoplasms	상세
Timtraxanib	AVI-3207	Phase 1 Clinical	Avixgen	Macular Degeneration	상세
Pamufetinib	TAS-115	Phase 1 Clinical	Otsuka Pharmaceutical Co Ltd, Taiho Pharmaceutical Co Ltd	Neoplasms	상세
nintedanib (Avalyn Pharma)		Phase 1 Clinical	Avalyn Pharma Inc	Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis	상세
Ramucirumab biosimilar (Sichuan Kelunbotai Biopharmaceutical)		Phase 1 Clinical	Sichuan Kelun Pharmaceutical Co Ltd	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Solid tumours; Stomach Neoplasms	상세
Tafetinib Malate	SIM-0702; SIM-1005; SIM-010603	Phase 1 Clinical	Jiangsu Simcere Pharmaceutical Co Ltd, Jilin Boda Pharmaceutical Co Ltd, Nanjing Yoko Biomedical Co Ltd	Neoplasms	상세
Nintedanib Esylate Inhalation Powder(Cspc)		Phase 1 Clinical	Cspc-Nbp Pharmaceutical Co Ltd	Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis	상세
JSKN-027	JSKN027; JSKN-027	Phase 1 Clinical	Alphamab Oncology	Neoplasms; Solid tumours	상세
DPH-001	DPH-001; DPH001	Phase 1 Clinical	Disruptive Pharma AB		상세
QBH-196	QBH-196	Phase 1 Clinical	Shenyang Pharmaceutical University	Solid tumours; Stomach Neoplasms	상세
Ramucirumab biosimilar (Klus Pharma)	A168; A-168	Phase 1 Clinical	Klus Pharma Inc		상세
MNKD-201	MNKD-201; MKND-201	Phase 1 Clinical	MannKind Corp	Idiopathic Pulmonary Fibrosis	상세
ETN-101	ETN101; ETN-101; MBP-11901	Phase 1 Clinical	Etnova Therapeutics Corp	Carcinoma, Hepatocellular; Liver Neoplasms	상세
RP-904		Phase 1 Clinical	Risen (Suzhou) Pharma Tech Co Ltd	Solid tumours	상세
RA1115-B1	RA1115-B1	Phase 1 Clinical	Suzhou Raymon Pharmaceuticals Co Ltd	Diabetic macular oedema; Macular Degeneration; Wet Macular Degeneration	상세
PZ-1	PZ-1	Phase 1 Clinical	Chongqing University Of Arts And Sciences	Solid tumours	상세
ICP-033	ICP-033	Phase 1 Clinical	Beijing Innocare Pharma Tech Co Ltd	Solid tumours	상세
PAN-90806	OSI-632; CP-632; CP-547632; PAN-90806	Phase 1 Clinical	Osi Pharmaceutical, Pfizer Inc	Abdominal Neoplasms; Diabetic Retinopathy; Fallopian Tube Neoplasms; Lung Neoplasms; Macular Degeneration; Ovarian Neoplasms; Peritoneal Neoplasms; Wet Macular Degeneration	상세
LMV-12(HE003)	LMV-12(HE003)	Phase 1 Clinical	Nanchang Hongyi Technology Co Ltd	Solid tumours	상세
Metatinib Trometamol	BMS-817378; SIM-817378	Phase 1 Clinical	Bristol-Myers Squibb Company	Colorectal Neoplasms; Liver Neoplasms; Solid tumours; Stomach Neoplasms	상세
NP-01 (Shijiazhuang No.4 Pharmaceutical/Nanjing Nadingfei Medical Technology)	NP-01	Phase 1 Clinical	Nanjing Nadingfei Pharmaceutical Technology Co Ltd, Shijiazhuang No 4 Pharmaceutical Co Ltd	Liver Neoplasms; Lung Neoplasms; Solid tumours; Stomach Neoplasms	상세
FNX-006	FNX-006	Phase 1 Clinical	Chengdu Fannuoxi Biomedical Technology Co Ltd, Sichuan University	Melanoma; Triple Negative Breast Neoplasms	상세
Sorafenib tosylate (Bio-Synectics)	BS-104	Clinical	Bio-Synectics Inc		상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Anlotinib Dihydrochloride	AL-3818	Approved	Advenchen Laboratories Llc, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	福可维	Mainland China	Carcinoma, Non-Small-Cell Lung	Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	2018-05-08	Bile Duct Diseases; Bone Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Colorectal Neoplasms; Craniopharyngioma; Endometrial Neoplasms; Esophageal Squamous Cell Carcinoma; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Gastroesophageal Junction Neoplasms; Gastrointestinal Stromal Tumors; Glioma; Head and Neck Neoplasms; Hepatic Insufficiency; Leiomyosarcoma; Liver Dysfunction; Lung Diseases, Interstitial; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Medullary thyroid cancer (MTC); Melanoma; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms; Neuroendocrine Tumors; Osteoma; Ovarian Neoplasms; Peritoneal Neoplasms; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Synovial; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Thoracic Neoplasms; Thyroid Neoplasms; Urologic Neoplasms; Uterine Cervical Neoplasms	상세
Lenvatinib Mesilate	E-7080; MK-7902; ER-203492-00	Approved	Eisai Co Ltd	Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛	United States	Thyroid Neoplasms	Eisai Inc	2015-02-13	Adenocarcinoma; Adenocarcinoma of Lung; Adenocarcinoma, Follicular; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Endometrial Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Glioma; Hepatic Insufficiency; Liver Diseases; Liver Neoplasms; Lymphoma; Melanoma; Neoplasm Metastasis; Neoplasms; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Paraganglioma; Pheochromocytoma; Renal Insufficiency; Solid tumours; Stomach Neoplasms; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Uterine Cervical Neoplasms	상세
Axitinib	PF-01367866; AG-13736; AG-013736	Approved	Pfizer Inc	英立达, Inlyta	United States	Carcinoma, Renal Cell	Pf Prism Cv	2012-01-27	Adenocarcinoma; Adrenal Cortex Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Adenoid Cystic; Carcinoma, Ductal; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cholangiocarcinoma; Colorectal Neoplasms; Glioblastoma; Hepatic Insufficiency; Kidney Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Melanoma; Mesothelioma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Neoplasms; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Paraganglioma; Pheochromocytoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thyroid Neoplasms; Uveal melanoma	상세
Regorafenib	DAST; BAY-73-4506	Approved	Bayer AG	Stivarga, Resihance	United States	Colorectal Neoplasms	Bayer Healthcare Pharmaceuticals Inc	2012-09-27	Adenocarcinoma; Adenoma; Bile Duct Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Esophageal adenocarcinoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gastrinoma; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Glucagonoma; Hemangiosarcoma; Insulinoma; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Melanoma; Meningioma; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma; Sarcoma, Ewing; Solid tumours; Somatostatinoma; Stomach Neoplasms; Thymoma; Thyroid Neoplasms	상세
Nintedanib Esylate	BIBF-1120	Approved	C.H. Boehringer Sohn Ag & Co. Kg	Ofev, Vargatef	United States	Idiopathic Pulmonary Fibrosis	Boehringer Ingelheim International Gmbh	2014-10-15	Adenocarcinoma, Clear Cell; Appendiceal Neoplasms; Asbestosis; Astrocytoma; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Endometrial Stromal Tumors; Esophageal Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Glioblastoma; Gliosarcoma; Hepatic Insufficiency; Idiopathic Pulmonary Fibrosis; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Mesothelioma; Multiple Myeloma; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Pulmonary Fibrosis; Radiation Pneumonitis; Rejection of lung transplantation; Sarcoma; Scleroderma, Systemic; Silicosis; Small Cell Lung Carcinoma; Solid tumours; systemic sclerosis-associated interstitial lung disease; Telangiectasia, Hereditary Hemorrhagic; Uterine Neoplasms	상세
Vorolanib	CM-082; X-82; EYP-1901; XV-615	Approved	Tyrogenex Inc	伏美纳, DURAVYU™	Mainland China	Carcinoma, Renal Cell	Betta Pharmaceuticals Co Ltd	2023-06-07	Adenocarcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Choroidal Neovascularization; Diabetic macular oedema; Diabetic Retinopathy; Eye Diseases; Gastroesophageal Junction Neoplasms; Kidney Neoplasms; Leukemia, Myeloid, Acute; Macular Degeneration; Melanoma; Neoplasms; Pancreatic Neoplasms; Retinal Degeneration; Retinal Diseases; Small Cell Lung Carcinoma; Solid tumours; Stomach Neoplasms; Wet Macular Degeneration	상세
Tivozanib	KRN-951; KHK-4951; KHK4951; UNII-172030934T; ASP-4130; Kil-8951; AV-951	Approved	Kyowa Hakko Kirin Co Ltd	Fotivda, FOTIVDA	EU	Carcinoma, Renal Cell	Recordati Netherlands BV	2017-08-24	Bile Duct Neoplasms; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Cholangiocarcinoma; Colorectal Neoplasms; Fallopian Tube Neoplasms; Gastrointestinal Neoplasms; Hepatic Insufficiency; Metastatic breast cancer; Ovarian Neoplasms; Peritoneal Neoplasms; Sarcoma; Solid tumours; Triple Negative Breast Neoplasms; Wet Macular Degeneration	상세
Apatinib Mesylate	YN-968D1	Approved	Advenchen Laboratories Llc	艾坦, Aitan	Mainland China	Stomach Neoplasms	Jiangsu shengdi Medicine Co Ltd	2014-10-17	Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Colorectal Neoplasms; Esophageal Neoplasms; Esthesioneuroblastoma, Olfactory; Fallopian Tube Neoplasms; Gastroesophageal Junction Neoplasms; Head and Neck Neoplasms; Lung Neoplasms; Melanoma; Metastatic breast cancer; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms	상세
Ripretinib	DCC-2618	Approved	Deciphera Pharmaceuticals	Qinlock, 擎乐	United States	Gastrointestinal Stromal Tumors	Deciphera Pharmaceuticals Llc	2020-05-15	Gastrointestinal Stromal Tumors; Mastocytosis, Systemic; Neoplasms	상세
Ramucirumab	IMC-1121; IMC-1C11; LY-3009806; IMC-1121-B; BLA-125477	Approved	Dyax Pharma	Cyramza	United States	Gastrointestinal Stromal Tumors	Eli Lilly And Company	2014-04-21	Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Stromal Tumors; Melanoma; Metastatic breast cancer; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Solid tumours; Stomach Neoplasms; Ureteral Neoplasms; Urethral Neoplasms; Urologic Neoplasms	상세
Sunitinib Malate	PNU-290940AD; PHA-290940AD; SCAI-003; SU-010398; SU-11248; GB-102; PHA-290940; PNU-290940; SU-011248-L-malate salt	Approved	Pfizer Inc	Sutent, 索坦	United States	Gastrointestinal Stromal Tumors; Carcinoma, Renal Cell	Cppi Cv	2006-01-26	Abdominal Neoplasms; Adenocarcinoma; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenocortical Carcinoma; AIDS-Related Complex; Amyloidosis; Angioimmunoblastic T-cell Lymphoma; Astrocytoma; Barrett Esophagus; Brain metastases; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma; Carcinoma, Acinar Cell; Carcinoma, Adenoid Cystic; Carcinoma, Adenosquamous; Carcinoma, Embryonal; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Choriocarcinoma; Chronic eosinophilic leukemia (CEL); Cognition Disorders; Colorectal Neoplasms; Diabetic macular oedema; Endodermal Sinus Tumor; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Fibrosarcoma; Gastrointestinal Stromal Tumors; Germinoma; Glioblastoma; Glioma; Gliosarcoma; Head and Neck Neoplasms; Hemangi	상세
Pazopanib Hydrochloride	GSK-786034; GW-786034B; SB-786034; GW-786034	Approved	Glaxosmithkline Plc, Novartis Pharma Ag	维全特, Armala, Votrient, Patorma	United States	Carcinoma, Renal Cell; Sarcoma	Novartis Pharma Ag	2009-10-19	Adenocarcinoma, Follicular; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Embryonal; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Chondrosarcoma; Chondrosarcoma, Extraskeletal Myxoid; Choriocarcinoma; Colorectal Neoplasms; Dermatofibrosarcoma; Endodermal Sinus Tumor; Epistaxis; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Gastrinoma; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Genital Neoplasms, Female; Germinoma; Glioblastoma; Glioma; Gliosarcoma; Glucagonoma; Hemangiosarcoma; Herpes Genitalis; Herpes Simplex; HIV Infections; Hormone-Resistant Prostate Neoplasms; Insulinoma; Leiomyosarcoma; Leukemia, Myeloid, Acute; Liposarcoma; Lung Neoplasms; Lymphoma; Macular Degeneration; Medullary thyroid cancer (MTC); Melanoma; Mesothelioma; Multiple Endocrine Neoplasia T	상세
Cabozantinib S-malate	XL-184; BMS-907351; RO7047650; RO-7047650	Approved	Exelixis Inc	Cometriq, Cabometyx	United States	Thyroid Neoplasms; Carcinoma, Neuroendocrine	Exelixis Inc	2012-11-29	Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Astrocytoma; Bile Duct Neoplasms; Bone metastases; Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Glioblastoma; Glioma; Gliosarcoma; Hepatic Insufficiency; Hepatoblastoma; HIV Infections; Kidney Neoplasms; Leiomyosarcoma; Leukemia, Myeloid, Acute; Lymphoma; Medullary thyroid cancer (MTC); Melanoma; Meningioma; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrin	상세
Fruquintinib	HMPL-013; TAK-113	Approved		FRUZAQLA, Aiyoute, Elunate, 爱优特	Mainland China	Colorectal Neoplasms	Hutchison Medipharma Ltd	2018-09-04	Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Hepatic Insufficiency; Lung Neoplasms; Metastatic breast cancer; Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms; Renal Insufficiency; Sarcoma; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms	상세
Sorafenib Tosylate	NSC-724772; BAY-43-0006; BAY-43-9006; BAY-54-9085	Approved	Onyx Pharmaceuticals Inc	Nexavar, 多吉美	United States	Carcinoma, Renal Cell	Bayer Healthcare Pharmaceuticals Inc	2005-12-01	Abdominal Neoplasms; Adenocarcinoma; Angioimmunoblastic T-cell Lymphoma; Astrocytoma; Bile Duct Neoplasms; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Burkitt Lymphoma; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carcinoma, Verrucous; Cholangiocarcinoma; Colonic Neoplasms; Esophageal Neoplasms; Facial Neoplasms; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Gallbladder Neoplasms; Gastrinoma; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Gliosarcoma; Glucagonoma; Head and Neck Neoplasms; Heart Arrest; Hemangiosarcoma; Hepatopulmonary Syndrome; Histiocytoma, Malignant Fibrous; Hypertension, Portal; Hypopharyngeal Neoplasms; Insulinoma; Kidney Diseases; Kidney Neoplasms; Laryngeal Diseases; Laryngeal Neoplasms; Leiomyosarcoma; Leukemia, Basophilic, Acute; Leukemia, Eosin	상세
Vandetanib	AZD-6474; CH-331; ZD-6474	Approved	Astrazeneca Plc	Zactima, Caprelsa	United States	Carcinoma, Neuroendocrine; Thyroid Neoplasms	Genzyme Corp	2011-04-06	Abdominal Neoplasms; Adenocarcinoma; Ampullary Carcinoma; Anus Neoplasms; Astrocytoma; Bile Duct Neoplasms; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Diffuse Intrinsic Pontine Glioma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Glioma; Gliosarcoma; Head and Neck Neoplasms; Intestinal Neoplasms; Kidney Neoplasms; Lung Neoplasms; Lymphoma; Lymphoproliferative Disorders; Medullary thyroid cancer (MTC); Mesothelioma; Metastatic breast cancer; Multiple Endocrine Neoplasia Type 2a; Multiple Endocrine Neoplasia Type 2b; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Oligodendroglioma; Ovarian Neoplasms; Pancreatic Neoplasms; Paraganglioma; Peritoneal Neoplasms; Pheochromocytoma; Pleural Effusion; Precancerous Co	상세
Famitinib Malate	SHR-1020	Approved	Jiangsu Hengrui Medicine Co Ltd	艾比特	Mainland China	Uterine Cervical Neoplasms	Jiangsu Hengrui Medicine Co Ltd	2025-05-27	Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Stromal Tumors; Genital Neoplasms, Female; Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Metastatic breast cancer; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms; Ovarian Neoplasms; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma; Solid tumours; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Urologic Neoplasms; Uterine Cervical Neoplasms	상세
Midostaurin	PKC-412; PKC-412A; CGP-41231; CGP-41251	Approved	Novartis Pharma Ag	Rydapt	United States	Hematologic Neoplasms; Leukemia, Myeloid, Acute; Mastocytosis, Systemic; Leukemia, Mast-Cell	Novartis Pharmaceuticals Corp	2017-04-28	Hematologic Neoplasms; Hepatic Insufficiency; Leukemia; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute; Mastocytosis; Mastocytosis, Systemic; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma	상세