언어 선택

TrkB

TrkB 분자 정보

영어 이름	Neurotrophic tyrosine kinase receptor type 2	시판 약물 수	5
임상 약물 수	13	표적 별명	EC:2.7.10.1，EC 2.7.10，Tropomyosin-related kinase B，Trk-B，GP145-TrkB，NTRK2，Neurotrophic Receptor Tyrosine Kinase 2，Neurotrophic Tyrosine Kinase Receptor Type 2，TRKB，Neurotrophic Tyrosine Kinase， Receptor， Type 2，BDNF-Tropomyosine Receptor Kinase B，BDNF/NT-3 Growth Factors Receptor，Tyrosine Kinase Receptor B，TrkB Tyrosine Kinase，EC 2.7.10.1，EIEE58，OBHD，Receptor， trkB
최고 연구 개발 단계	Approved

영어 이름	Neurotrophic tyrosine kinase receptor type 2
표적 별명	EC:2.7.10.1，EC 2.7.10，Tropomyosin-related kinase B，Trk-B，GP145-TrkB，NTRK2，Neurotrophic Receptor Tyrosine Kinase 2，Neurotrophic Tyrosine Kinase Receptor Type 2，TRKB，Neurotrophic Tyrosine Kinase， Receptor， Type 2，BDNF-Tropomyosine Receptor Kinase B，BDNF/NT-3 Growth Factors Receptor，Tyrosine Kinase Receptor B，TrkB Tyrosine Kinase，EC 2.7.10.1，EIEE58，OBHD，Receptor， trkB
시판 약물 수	5
임상 약물 수	13
최고 연구 개발 단계	Approved

TrkB 제품 목록

속성
Protein (3)Cell (2)
제품 라이브러리
온라인 (5)
종
Human (5)
태그
Fc Tag (1)His Tag (1)Tag Free (1)His Tag & Avi Tag (1)- (1)
마커
Unconjugated (2)- (2)Biotin-labeled (1)

제품 번호	종	발현 시스템	제품 설명
CHEK-ATF289	Human	HEK293	Human TrkB (Luc) HEK293 Reporter Cell
CHEK-ATP082	Human	HEK293	HEK293/Human TrkB Stable Cell Line
NT2-H5228	Human	HEK293	Human TrkB / NTRK2 Protein, His Tag
NT2-H5254	Human	HEK293	Human TrkB / NTRK2 Protein, Fc Tag
NT2-H82E3	Human	HEK293	Biotinylated Human TrkB / NTRK2 Protein, His,Avitag™ (MALS verified)

총 수량5

TrkB분자 배경

This gene encodes a member of the neurotrophic tyrosine receptor kinase(NTRK)family.This kinase is a membrane-bound receptor that upon neurotrophin binding,phosphorylates itself and members of the MAPK pathway.Signalling through this kinase leads to cell differentiation.Mutations in this gene have been associated with obesity and mood disorders.

TrkB분자 별명

NTRK2,TRKB,GP145-TrkB

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Lestaurtinib	SPM-924; A-154475.0; KT-5555; SP-924; CEP-701	Phase 3 Clinical	Kyowa Hakko Kirin Co Ltd	Bone Marrow Neoplasms; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Neuroblastoma; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Psoriasis; Thrombocythemia, Essential	상세
Merestinib	5OGS5K699E; LY-2801653	Phase 2 Clinical	Eli Lilly And Company	Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours	상세
FCN-011	FCN-011	Phase 2 Clinical		Solid tumours	상세
MT-200605	MT-200605; MT200605	Phase 2 Clinical	Shaanxi Micot Pharmaceutical Technology Co Ltd	Brain Injuries; Ischemic Stroke; Nervous System Diseases; Obesity; Overweight; Stroke	상세
Emzeltrectinib	CT-3417; TQB-3558	Phase 1 Clinical	Beijing Centaurus Biopharma Co Ltd, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	Solid tumours	상세
ACD-856	ACD-856	Phase 1 Clinical	Alzecure Pharma Ab	Alzheimer Disease; Cognition Disorders	상세
HG-030	HG-030	Phase 1 Clinical	Hitgen Inc	Solid tumours	상세
FB_-1002	FB_-1002; FB-1002; 4B02-01	Phase 1 Clinical	4b Technologies (Suzhou) Ltd	Amyotrophic Lateral Sclerosis; Depressive Disorder	상세
FB-1001	FB_-1001; FB-1001; FB1001	Phase 1 Clinical	4b Technologies (Suzhou) Ltd	Glaucoma; Glaucoma, Angle-Closure; Optic Nerve Diseases; Optic Neuropathy, Ischemic	상세
1-D-228	1D228; 1-D-228	Phase 1 Clinical	Guangdong Lewwin Pharmaceutical Research Institute Co Ltd, Guangzhou Zhongkelian Pharmaceutical Research Co Ltd	Carcinoma, Non-Small-Cell Lung	상세
BrAD-R13	BrAD-R13; BrADR13	Phase 1 Clinical	Shenzhen Braegen Pharmaceutical Co Ltd	Alzheimer Disease	상세
T-1301	T-1301; DBPR-216; BPR-1J481; BPR1J481	Phase 1 Clinical	Taivex Therapeutics Corp	Lymphoma; Solid tumours	상세
Paltimatrectinib	PBI-200	Phase 1 Clinical	Pyramid Biosciences	Brain Neoplasms; Desmoplastic Small Round Cell Tumor; Solid tumours	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Taletrectinib Adipate	DS-6051b; DS-6051a; DS-6051; AB-106; IBI-344	Approved	Daiichi Sankyo Co Ltd	达伯乐, DOVBLERON, IBTROZI	Mainland China	Carcinoma, Non-Small-Cell Lung	AnHeart Therapeutics Co Ltd	2024-12-17	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Neoplasms; Solid tumours	상세
Entrectinib	NMS-E628; RXDX-101; RG-6268	Approved	Nerviano Medical Sciences Srl	Rozlytrek, 罗圣全	Japan	Carcinoma, Non-Small-Cell Lung	Chugai Pharmaceutical Co Ltd	2019-06-18	Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lymphoma, Large-Cell, Anaplastic; Lymphoproliferative Disorders; Melanoma; Neoplasms; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Salivary Gland Neoplasms; Sarcoma; Solid tumours; Thyroid Cancer, Papillary	상세
Larotrectinib sulfate	LOXO-101; ARRY-470; BAY-2757556	Approved	Array Biopharma	Vitrakvi, 维泰凯	United States	Solid tumours	Bayer Healthcare	2018-11-26	Breast Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fibrosarcoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Hepatoblastoma; Histiocytic Sarcoma; Histiocytosis, Langerhans-Cell; Leukemia; Liver Neoplasms; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Multiple Myeloma; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Wilms Tumor; Xanthogranuloma, Juvenile	상세
Repotrectinib	TPX-0005; BMS-986472; ZL-2308	Approved	Turning Point Therapeutics Inc	Augtyro, 奥凯乐	United States	Carcinoma, Non-Small-Cell Lung	Bristol-Myers Squibb Company	2023-11-15	Brain metastases; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Hepatic Insufficiency; Lymphoma; Neoplasms; Solid tumours	상세
Cabozantinib S-malate	XL-184; BMS-907351; RO7047650; RO-7047650	Approved	Exelixis Inc	Cometriq, Cabometyx	United States	Thyroid Neoplasms; Carcinoma, Neuroendocrine	Exelixis Inc	2012-11-29	Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Astrocytoma; Bile Duct Neoplasms; Bone metastases; Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Glioblastoma; Glioma; Gliosarcoma; Hepatic Insufficiency; Hepatoblastoma; HIV Infections; Kidney Neoplasms; Leiomyosarcoma; Leukemia, Myeloid, Acute; Lymphoma; Medullary thyroid cancer (MTC); Melanoma; Meningioma; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrin	상세