언어 선택

TrkA

TrkA 분자 정보

영어 이름	Nerve growth factor receptor Trk-A	시판 약물 수	5
임상 약물 수	24	표적 별명	P140-TrkA，Gp140trk，MTC，TRK，Oncogene TRK，EC 2.7.10.1，TRK1，Receptor， trkA，High Affinity Nerve Growth Factor Receptor，Tropomyosin-Related Kinase A，TRKA，Trk-A，Tyrosine kinase receptor，Neurotrophic Receptor Tyrosine Kinase 1，Neurotrophic Tyrosine Kinase， Receptor， Type 1，EC 2.7.10，EC:2.7.10.1，NTRK1，Neurotrophic tyrosine kinase receptor type 1，TRK1-transforming tyrosine kinase protein，Tyrosine kinase receptor A
최고 연구 개발 단계	Approved

영어 이름	Nerve growth factor receptor Trk-A
표적 별명	P140-TrkA，Gp140trk，MTC，TRK，Oncogene TRK，EC 2.7.10.1，TRK1，Receptor， trkA，High Affinity Nerve Growth Factor Receptor，Tropomyosin-Related Kinase A，TRKA，Trk-A，Tyrosine kinase receptor，Neurotrophic Receptor Tyrosine Kinase 1，Neurotrophic Tyrosine Kinase， Receptor， Type 1，EC 2.7.10，EC:2.7.10.1，NTRK1，Neurotrophic tyrosine kinase receptor type 1，TRK1-transforming tyrosine kinase protein，Tyrosine kinase receptor A
시판 약물 수	5
임상 약물 수	24
최고 연구 개발 단계	Approved

TrkA 제품 목록

속성
Protein (2)Cell (2)
제품 라이브러리
온라인 (4)
종
Human (4)
태그
Mouse IgG Fc Tag (2)- (1)Tag Free (1)
마커
Unconjugated (2)- (2)

제품 번호	종	발현 시스템	제품 설명
HOT TRA-H5259	Human	HEK293	Human TrkA / NTRK1 (33-417) Protein, Mouse IgG2a Fc Tag
CHEK-ATF093	Human	HEK293	Human TrkA (Luc) HEK293 Reporter Cell
CHEK-ATP192	Human	HEK293	HEK293/Human TrkA Stable Cell Line
TRA-H5253	Human	HEK293	Human TrkA / NTRK1 (192-402) Protein, Mouse IgG2a Fc Tag

총 수량4

TrkA분자 배경

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

TrkA분자 별명

TrkA,NTRK1,MTC,TRK,TRKA,Trk-A

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Tavilermide	MIM-D3; NMG938VJ6T (UNII code)	Phase 3 Clinical	Mimetogen Pharmaceuticals	Dry Eye Syndromes; Keratoconjunctivitis Sicca; Xerophthalmia	상세
Lestaurtinib	SPM-924; A-154475.0; KT-5555; SP-924; CEP-701	Phase 3 Clinical	Kyowa Hakko Kirin Co Ltd	Bone Marrow Neoplasms; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Neuroblastoma; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Psoriasis; Thrombocythemia, Essential	상세
SNA-125	CT-340; SNA-125	Phase 2 Clinical	Creabilis Sa, Sienna Biopharmaceuticals Inc	Dermatitis, Atopic; Pruritus; Psoriasis	상세
OPN-7486	PLX-7486; PLX7486-TsOH	Phase 2 Clinical	Plexxikon Inc	Giant Cell Tumor of Tendon Sheath; Neoplasms; Solid tumours	상세
Merestinib	5OGS5K699E; LY-2801653	Phase 2 Clinical	Eli Lilly And Company	Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours	상세
Milciclib maleate	PHA-848125; TZLS-201; PHA-848125C; PHA-125; PHA-848125AC	Phase 2 Clinical	Nerviano Medical Sciences Srl, Tiziana Life Sciences Plc	Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Solid tumours; Thymoma	상세
FCN-011	FCN-011	Phase 2 Clinical		Solid tumours	상세
Recombinant human nerve growth factor (Xintrum Pharmacouticals)	rh-NGF; ZX1305; ZX-1305; ZX1305E; ZX-1305-E	Phase 2 Clinical	Jiangsu Zhongxin Pharmaceutical Co Ltd	Glaucoma, Open-Angle; Keratitis; Optic Nerve Injuries	상세
AK-1830	AK-1830; ARRY-954	Phase 2 Clinical	Array Biopharma	Low Back Pain	상세
CNTX-0066	CNTX-0066	Phase 2 Clinical	Centrexion Therapeutics Corp	Osteoarthritis, Knee	상세
STSP-0902	STSP-0902; STSP0902	Phase 2 Clinical	Staidson(Beijing) Biopharmaceuticals Co Ltd	Asthenozoospermia; Keratitis; Neurotrophic Keratitis; Oligospermia	상세
BEN-2293	BEN-00002293; BEN-2293	Phase 2 Clinical	Benevolentai Bio Ltd	Dermatitis, Atopic	상세
VMD-928	VMD-928	Phase 2 Clinical	Vm Oncology Llc	Carcinoma, Adenoid Cystic; Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Head and Neck Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Mesothelioma; Pancreatic Neoplasms; Salivary Gland Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck	상세
Emzeltrectinib	CT-3417; TQB-3558	Phase 1 Clinical	Beijing Centaurus Biopharma Co Ltd, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	Solid tumours	상세
BPI-28592	BPI-28592	Phase 1 Clinical	Betta Pharmaceuticals Co Ltd	Neoplasm Metastasis; Solid tumours	상세
ACD-856	ACD-856	Phase 1 Clinical	Alzecure Pharma Ab	Alzheimer Disease; Cognition Disorders	상세
HG-030	HG-030	Phase 1 Clinical	Hitgen Inc	Solid tumours	상세
CSCJC-3456	CSCJC3456; CSCJC-3456	Phase 1 Clinical	Changshan ConjuChem BioPharmaceutical Research and Development (Hebei) Co Ltd, Hebei Changshan Biochemical Pharmaceutical Co Ltd	Solid tumours	상세
BR-01T	BR01T; BR-01T	Phase 1 Clinical	Xiyuan Anjian Pharmaceutical (Shanghai) Co Ltd	Low Back Pain	상세
HT006.2.2	HT006.2.2; HT-006.2.2	Phase 1 Clinical	Wuhan Hiteck Biological Pharma Co Ltd	Keratitis	상세
T-1301	T-1301; DBPR-216; BPR-1J481; BPR1J481	Phase 1 Clinical	Taivex Therapeutics Corp	Lymphoma; Solid tumours	상세
Paltimatrectinib	PBI-200	Phase 1 Clinical	Pyramid Biosciences	Brain Neoplasms; Desmoplastic Small Round Cell Tumor; Solid tumours	상세
FCN-098	FCN-098; FCN098	Phase 1 Clinical		Neoplasms; Solid tumours	상세
E-2511	E2511; E-2511	Phase 1 Clinical	Eisai Inc		상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Taletrectinib Adipate	DS-6051b; DS-6051a; DS-6051; AB-106; IBI-344	Approved	Daiichi Sankyo Co Ltd	达伯乐, DOVBLERON, IBTROZI	Mainland China	Carcinoma, Non-Small-Cell Lung	AnHeart Therapeutics Co Ltd	2024-12-17	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Neoplasms; Solid tumours	상세
Entrectinib	NMS-E628; RXDX-101; RG-6268	Approved	Nerviano Medical Sciences Srl	Rozlytrek, 罗圣全	Japan	Carcinoma, Non-Small-Cell Lung	Chugai Pharmaceutical Co Ltd	2019-06-18	Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lymphoma, Large-Cell, Anaplastic; Lymphoproliferative Disorders; Melanoma; Neoplasms; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Salivary Gland Neoplasms; Sarcoma; Solid tumours; Thyroid Cancer, Papillary	상세
Regorafenib	DAST; BAY-73-4506	Approved	Bayer AG	Stivarga, Resihance	United States	Colorectal Neoplasms	Bayer Healthcare Pharmaceuticals Inc	2012-09-27	Adenocarcinoma; Adenoma; Bile Duct Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colonic Neoplasms; Colorectal Neoplasms; Esophageal adenocarcinoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gastrinoma; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Glucagonoma; Hemangiosarcoma; Insulinoma; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Melanoma; Meningioma; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma; Sarcoma, Ewing; Solid tumours; Somatostatinoma; Stomach Neoplasms; Thymoma; Thyroid Neoplasms	상세
Larotrectinib sulfate	LOXO-101; ARRY-470; BAY-2757556	Approved	Array Biopharma	Vitrakvi, 维泰凯	United States	Solid tumours	Bayer Healthcare	2018-11-26	Breast Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fibrosarcoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Hepatoblastoma; Histiocytic Sarcoma; Histiocytosis, Langerhans-Cell; Leukemia; Liver Neoplasms; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Multiple Myeloma; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Wilms Tumor; Xanthogranuloma, Juvenile	상세
Repotrectinib	TPX-0005; BMS-986472; ZL-2308	Approved	Turning Point Therapeutics Inc	Augtyro, 奥凯乐	United States	Carcinoma, Non-Small-Cell Lung	Bristol-Myers Squibb Company	2023-11-15	Brain metastases; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Hepatic Insufficiency; Lymphoma; Neoplasms; Solid tumours	상세