TPBG

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TPBG 분자 정보

Molecule Name

Trophoblast glycoprotein

분자 별명

TPBG,5T4,M6P1,5T4AG,WAIF1,5T4 oncofetal antigen,Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein

Drug Development Progress

임상 약물 수16

시판 약물 수0

최고 연구 개발 단계Phase 2 Clinical

표적 별명

Trophoblast glycoprotein，5T4 oncotrophoblast glycoprotein，5T4，TPBG，5T4 oncofetal antigen，M6P1，5T4 oncofetal trophoblast glycoprotein，Wnt-Activated Inhibitory Factor 1，WAIF1，5T4AG，5T4-AG

분자 배경

Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.

TPBG 제품 목록

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항체 프로젝트 거래 플랫폼

프로젝트 이름	프로젝트 단계	분자 유형	분자 출처	질병 영역	적응증
5T4 mAb - 01	Lead	Monoclonal	Humanized Mouse	Solid Tumor	Ovarian cancer,Lung cancer

프로젝트 이름: 5T4 mAb - 01
프로젝트 단계: Lead
분자 유형: Monoclonal
분자 출처: Humanized Mouse
질병 영역: Solid Tumor
적응증: Ovarian cancer,Lung cancer

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Naptumomab estafenatox	TTS-CD3; ABR-217620	Phase 2 Clinical	Active Biotech Ab	Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Melanoma; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	상세
ALG.APV-527	ALG.APV 527; ADC-1016; ATOR-1016; ALG.APV-527; ALG-APV-527	Phase 2 Clinical	Alligator Bioscience Ab, Aptevo Therapeutics Inc	Neoplasms; Solid tumours	상세
JK-06	JK-06	Phase 2 Clinical	Xinlitai (Chengdu) Biological Technology Co Ltd	Neoplasms; Solid tumours	상세
TUB-030	TUB-030	Phase 2 Clinical	Tubulis GmbH	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	상세
ACR-246	ACR246; ACR-246; ADC2154; ADC-2154	Phase 2 Clinical	Hangzhou Adcoris Biopharmacy Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Esophageal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Uterine Cervical Neoplasms	상세
IBR-854	IBR854; IBR-854	Phase 2 Clinical	Imbioray (Hangzhou) Biomedicine Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Solid tumours	상세
SYD-1875	SYD-1875	Phase 1 Clinical	Synthon Bv	Solid tumours	상세
ASN-004	ASN-004	Phase 1 Clinical	Asana Biosciences Llc	Solid tumours	상세
anti-5T4 CAR NK-cell therapy (Wuxi Peapole's Hospital/Hangzhou Yingbairui Biomedical Technology)		Phase 1 Clinical	Imbioray (Hangzhou) Biomedicine Co Ltd	Solid tumours	상세
Naptumomab estafenatox/Durvalumab	NTX-352	Phase 1 Clinical	Neotx Therapeutics Ltd	Solid tumours	상세
XB-010	XB-010	Phase 1 Clinical	Exelixis Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Esophageal Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	상세
FTL-008.16	FTL-008.16; FTL008.16	Phase 1 Clinical	Sound(Chengdu)Biopharmacauticals Co Ltd	Solid tumours	상세
CBA-1535	CBA-1535	Phase 1 Clinical	Chiome Bioscience Inc	Carcinoma, Non-Small-Cell Lung; Mesothelioma; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms	상세
Anti-5T4 CAR-raNK Cell Therapy		Phase 1 Clinical	Imbioray (Hangzhou) Biomedicine Co Ltd	Solid tumours	상세
Prostate cancer vaccine(inactivated viral)(University of Oxford)		Clinical	University Of Oxford	Prostatic Neoplasms	상세
68Ga-NOTA-H006		Clinical	Huashan Hospital	Solid tumours	상세

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