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TOP2A

TOP2A

TOP2A 분자 정보

Molecule Name
Topoisomerase (DNA) II alpha
분자 별명
TOP2A,TOP2,DNA topoisomerase 2-alpha,DNA topoisomerase II,alpha isozyme
Drug Development Progress
임상 약물 수1
시판 약물 수1
최고 연구 개발 단계Approved
표적 별명
EC:5.6.2.2，EC 5.6.2.2，TOP2A，DNA topoisomerase 2-alpha，DNA topoisomerase II， alpha isozyme，DNA Topoisomerase II Alpha，Topoisomerase (DNA) II Alpha 170kDa，TOP2，DNA Topoisomerase (ATP-Hydrolyzing)，DNA Topoisomerase II， 170 KD，EC 5.99.1.3，TP2A，DNA Gyrase
분자 배경
DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.

TOP2A 제품 목록

Species
  • Human（1）
Tag
  • Tag Free（1）
Host
  • E. coli（1）
Conjugate
  • Unconjugated（1）
Grade
  • RUO（1）
Low Endotoxin
  • No（1）
분자Cat. No.Product Name종Host구조순도Activity규격 및 가격
TOP2A
TOA-H5117
Human TOP2A / TOP2 Protein, Tag Free
Human
E. coli
SDS-PAGE

$310.00

20ug
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임상 약물 정보

영어 이름연구 코드연구 개발 단계회사적응증임상 시험
Novobiocin SodiumPhase 1 Clinical
Bacterial Infections; Neoplasms; Solid tumours
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시판 약물 정보

영어 이름연구 코드연구 개발 단계회사가장 빠른 브랜드 이름가장 빠른 승인 국가가장 빠른 적응증가장 빠른 승인 회사가장 빠른 승인 날짜적응증임상 시험
Etoposide phosphateBMY-40481ApprovedBristol-Myers Squibb CompanyEtopophosUnited StatesLymphoma, Non-Hodgkin; Multiple Myeloma; Testicular Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hodgkin Disease; Small Cell Lung CarcinomaCheplapharm Arzneimittel Gmbh1996-05-17
Adrenocortical Carcinoma; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; CNS Embryonal Tumor; Germinoma; Hodgkin Disease; Kidney Neoplasms; Leukemia; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neoplasms, Gonadal Tissue; Neoplasms, Plasma Cell; Neuroblastoma; Neutropenia; Ovarian Neoplasms; Plasmacytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Sarcoma, Ewing; Small Cell Lung Carcinoma; Solid tumours; Testicular Neoplasms; Thrombocytopenia; Uterine Cervical Neoplasms
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