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TNFSF11

TNFSF11

TNFSF11 분자 정보

Molecule Name
Tumor necrosis factor ligand superfamily member 11
분자 별명
RANKL,CD254,TRANCE,OPGL,ODF
Drug Development Progress
임상 약물 수12
시판 약물 수19
최고 연구 개발 단계Approved
표적 별명
Osteoclast differentiation factor，TRANCE，TNFSF11，TNF-related activation-induced cytokine，Tumor necrosis factor ligand superfamily member 11，CD254，TNF Superfamily Member 11，Osteoprotegerin Ligand，Receptor Activator Of Nuclear Factor Kappa B Ligand，Tumor Necrosis Factor Superfamily Member 11，ODF，RANKL，OPGL，CD254 Antigen，HRANKL2，TNLG6B，OPTB2，SOdf，RANK Ligand，Tumor Necrosis Factor (Ligand) Superfamily， Member 11，Receptor Activator Of Nuclear Factor Kappa-B Ligand，Tumor Necrosis Factor Ligand 6B
분자 배경
Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.

TNFSF11 제품 목록

Species
  • Human（5）
  • Cynomolgus（2）
  • Rat（1）
  • Rhesus macaque（1）
Tag
  • His Tag（3）
  • Fc Tag（2）
  • His Tag & Avi Tag（2）
  • Fc Tag & Avi Tag（1）
  • Tag Free（1）
Host
  • HEK293（9）
Conjugate
  • Unconjugated（6）
  • Biotin-labeled（3）
Grade
  • RUO（8）
  • PG (pre-GMP)（1）
Low Endotoxin
  • Yes（1）
  • No（8）
분자Cat. No.Product Name종Host구조순도Activity규격 및 가격
TNFSF11
HOT
RAL-H5217
Human TNFSF11 / RANKL / CD254 Protein, premium grade
Human
HEK293
MALSSDS-PAGE
ELISA

$185.00

20ug
TNFSF11
HOTAvitag
RAL-H82Q5
Biotinylated Human TNFSF11 / RANKL / CD254 Protein, His,Avitag™, active trimer (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$380.00

25ug
TNFSF11
HOT
RAL-H5240
Human TNFSF11 / RANKL / CD254 Protein, His Tag, active trimer, low endotoxin (Mass Spec & MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISASPRBLI

$360.00

50ug
TNFSF11
RAL-C5243
Cynomolgus TNFSF11 / RANKL / CD254 Protein, His Tag, active trimer (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$360.00

50ug
TNFSF11
RAL-C5263
Cynomolgus TNFSF11 / RANKL / CD254 Protein, Fc Tag
Cynomolgus
HEK293
SDS-PAGE
ELISA

$360.00

50ug
TNFSF11
RAL-H5265
Human TNFSF11 / RANKL / CD254 Protein, Fc Tag
Human
HEK293
SDS-PAGE
ELISASPRBLI

$360.00

50ug
TNFSF11
Avitag
RAL-H82F9
Biotinylated Human TNFSF11 / RANKL / CD254 Protein, Avitag™,Fc Tag
Human
HEK293
SDS-PAGE
ELISA

$360.00

25ug
TNFSF11
RAL-R5243
Rhesus macaque TNFSF11 / RANKL / CD254 Protein, His Tag (HPLC verified)
Rhesus macaque
HEK293
HPLCSDS-PAGE
ELISA

$360.00

50ug
TNFSF11
Avitag
RAL-R82Q9
Biotinylated Rat TNFSF11 / RANKL / CD254 Protein, His,Avitag™
Rat
HEK293
SDS-PAGE
ELISA

$360.00

25ug
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임상 약물 정보

영어 이름연구 코드연구 개발 단계회사적응증임상 시험
Denosumab biosimilar(Shanghai Hansoh)HS-20090; HS-20090-2Phase 3 ClinicalJiangsu Hansoh Pharmaceutical Group Co Ltd, Shanghai Hansoh Biomedical Co Ltd
Bone Diseases; Bone metastases; Giant Cell Tumor of Bone; Hypercalcemia; Multiple Myeloma; Neoplasms; Nutritional and Metabolic Diseases; Osteoporosis, Postmenopausal; Solid tumours
상세
Recombinant human anti-RANKL momoclonal antibody (Qilu Pharmaceutical)Phase 3 ClinicalQilu Pharmaceutical Co Ltd
Neoplasms; Osteoporosis, Postmenopausal
상세
Denosumab biosimilar (GlycoNex)SPD8; SPD-8Phase 3 ClinicalGlyconex Inc
Neoplasms; Osteoporosis
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Denosumab biosimilar (Hetero Biopharma)Phase 3 ClinicalHetero Biopharma Ltd
Solid tumours
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Denosumab biosimilar(Curateq Biologics)BP-16Phase 3 ClinicalCuraTeQ Biologics Pvt Ltd
Osteoporosis, Postmenopausal
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Recombinant anti-RANKL monoclonal antibody(Jiangsu Pacific-Meinuoke)Phase 3 ClinicalJiangsu Pacific Minok Biopharmaceutical Co., Ltd.
Osteoporosis, Postmenopausal
상세
SHR-2017SHR-2017; SHR2017Phase 2 ClinicalSuzhou Suncadia Biopharmaceuticals Co Ltd
Bone metastases; Multiple Myeloma; Osteoporosis; Solid tumours
상세
LZM-004LZM-004Phase 1 ClinicalLivzon(Group) Pharmaceutical Factory
Bone metastases
상세
Recombinant human anti-RANKL antibody (Innovent Biologics)IBI-307Phase 1 Clinical
Osteoporosis
상세
GB-223GB-223; GB223Phase 1 ClinicalGenor Biopharma Co Ltd
Bone metastases; Bone Neoplasms; Giant Cell Tumor of Bone; Osteoporosis, Postmenopausal; Solid tumours
상세
Denosumab biosimilar (Kpc Pharmaceuticals)MV-088Phase 1 ClinicalKpc Pharmaceuticals Inc
Osteoporosis, Postmenopausal
상세
Denosumab biosimilar (Zhejiang Hisun)HS629Phase 1 ClinicalZhejiang Hisun Pharmaceutical Co Ltd
Bone metastases; Solid tumours
상세

시판 약물 정보

영어 이름연구 코드연구 개발 단계회사가장 빠른 브랜드 이름가장 빠른 승인 국가가장 빠른 적응증가장 빠른 승인 회사가장 빠른 승인 날짜적응증임상 시험
Denosumab biosimilar (Teva Pharmaceutical)TVB-009P; TVB-009ApprovedTeva Pharmaceutical Industries LtdPONLIMSI, DEGEVMAEUBone Resorption; Osteoporosis, Postmenopausal; Osteoporosis; Giant Cell Tumor of Bone; Neoplasms, Bone TissueTeva Gmbh2025-11-17
Bone Neoplasms; Bone Resorption; Giant Cell Tumor of Bone; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal
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Denosumab biosimilar (Henlius)HLX14; HLX-14ApprovedBilprevda, BildyosUnited StatesHypercalcemia; Giant Cell Tumors; Bone metastases; Osteoporosis, PostmenopausalShanghai Henlius Biotech Inc2025-08-29
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NarlumosbartJMT-103ApprovedShanghai Jmt-Bio Inc津立泰, 津立生Mainland ChinaGiant Cell Tumor of BoneShanghai Jmt-Bio Inc2023-09-05
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Denosumab biosimilar (Mabwell)9-MW-0311; 9MW0321; 9-MW0321; 9MW-0321; 9-MW-0321; TK-006; MW-032; MW-031; 9MW0311; 9-MW0311; 9MW-0311ApprovedJiangsu T-Mab Bio-Pharmaceuticals Co Ltd迈利舒, 迈卫健, MAIWEIJIAN, MAILISHUMainland ChinaOsteoporosis, PostmenopausalJiangsu T-Mab Bio-Pharmaceuticals Co Ltd2023-03-28
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Denosumab biosimilar (Qilu Pharma)QL-1206ApprovedQilu Pharmaceutical Co Ltd鲁可欣Mainland ChinaOsteoporosis, PostmenopausalQilu Pharmaceutical Co Ltd2023-09-28
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Denosumab biosimilar (Boan Biopharma/Luye)LY-01011; BA-1102; BA-6101; LY-06006ApprovedShandong Boan Biotechnology Co Ltd博洛加, Boluojia, Boyoubei, 博优倍Mainland ChinaOsteoporosis, PostmenopausalShandong Boan Biotechnology Co Ltd2022-11-08
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Denosumab biosimilar (Accord Healthcare)ApprovedAccord Healthcare SluJubereq, OsvyrtiEUOsteoporosis; Neoplasms, Bone Tissue; Giant Cell Tumor of Bone; Bone Resorption; Osteoporosis, PostmenopausalAccord Healthcare Slu2025-05-26
Bone metastases; Bone Resorption; Giant Cell Tumor of Bone; Hypercalcemia; Neoplasms, Bone Tissue; Osteoporosis; Osteoporosis, Postmenopausal
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DenosumabNSC-744010; AMG-162ApprovedAmgen IncProlia, Xgeva, Pralia, Ranmark, 普罗力EUOsteoporosis, PostmenopausalAmgen Europe Bv2010-05-26
Anorexia Nervosa; Arthritis, Rheumatoid; Arthropathy, Neurogenic; Bone Cysts, Aneurysmal; Bone Diseases; Bone Diseases, Metabolic; Bone metastases; Bone Neoplasms; Breast Diseases; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Squamous Cell; Cataract; Chondroblastoma; Colonic Neoplasms; Crohn Disease; Endocrine Gland Neoplasms; Feeding and Eating Disorders; Fibroma; Fibrous Dysplasia of Bone; Fractures, Bone; Giant Cell Tumor of Bone; Giant Cell Tumors; Glucocorticoid-induced osteoporosis; Granuloma, Giant Cell; Head and Neck Neoplasms; Hematologic Neoplasms; Hematopoietic stem cell transplantation (HSCT); Hodgkin Disease; Hormone-Resistant Prostate Neoplasms; Hypercalcemia; Kidney Neoplasms; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Metastatic breast cancer; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Osteoarthritis; Osteoarthritis, Knee; Osteoblastoma; Osteogenesis Imperfecta; Osteoporosis; Osteoporosis
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Denosumab biosimilar(Enzene Biosciences)ENZ-215ApprovedEnzene Biosciences LtdOsqayEUBone ResorptionTheramex Ireland Ltd2026-01-08
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Denosumab biosimilar (Alvotech Swiss)AVT-03; AVT03ApprovedAlvotech Swiss AgAcvybra, XbonzyEUGiant Cell Tumor of Bone; Osteoporosis, Postmenopausal; Bone Resorption; Neoplasms, Bone Tissue; OsteoporosisStada Arzneimittel Ag, Reddy Holding Gmbh2025-11-17
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Denosumab biosimilar(Mabxience)MB-09ApprovedMabxience SaZadenvi, Izamby, Enwylma, DenbrayceEUNeoplasms, Bone Tissue; Bone Resorption; Osteoporosis, Postmenopausal; Osteoporosis; Giant Cell Tumor of BoneZentiva Ks, Mabxience Research SL2025-06-26
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