언어 선택

TGF-beta RII

TGF-beta RII 분자 정보

영어 이름	Transforming growth factor beta receptor 2	시판 약물 수	0
임상 약물 수	8	표적 별명	NONHSAG034676，TGF-beta receptor type II，Transforming Growth Factor Beta Receptor 2，Transforming Growth Factor， Beta Receptor II Alpha，Transforming Growth Factor Beta Receptor Type IIC，Transforming growth factor-beta receptor type II，TbetaR-II，TGF-beta type II receptor，TGFBR2，Transforming Growth Factor， Beta Receptor II (70/80kDa)，Transforming Growth Factor Beta Receptor II，TGFR-2，Transforming Growth Factor， Beta Receptor II Epsilon，Transforming Growth Factor， Beta Receptor II Delta，Transforming Growth Factor， Beta Receptor II Gamma，EC 2.7.11，Transforming Growth Factor， Beta Receptor II Beta，TGF-Beta Receptor Type IIB，TGF-Beta Receptor Type-2，EC 2.7.11.30，TGFbeta-RII，TBR-Ii，LDS1B，LDS2B，TAAD2，TBRII，AAT3，FAA3，LDS2，RIIC，MFS2，Receptor， Transforming Growth Factor-beta Type II，EC:2.7.11.30
최고 연구 개발 단계	Phase 3 Clinical

영어 이름	Transforming growth factor beta receptor 2
표적 별명	NONHSAG034676，TGF-beta receptor type II，Transforming Growth Factor Beta Receptor 2，Transforming Growth Factor， Beta Receptor II Alpha，Transforming Growth Factor Beta Receptor Type IIC，Transforming growth factor-beta receptor type II，TbetaR-II，TGF-beta type II receptor，TGFBR2，Transforming Growth Factor， Beta Receptor II (70/80kDa)，Transforming Growth Factor Beta Receptor II，TGFR-2，Transforming Growth Factor， Beta Receptor II Epsilon，Transforming Growth Factor， Beta Receptor II Delta，Transforming Growth Factor， Beta Receptor II Gamma，EC 2.7.11，Transforming Growth Factor， Beta Receptor II Beta，TGF-Beta Receptor Type IIB，TGF-Beta Receptor Type-2，EC 2.7.11.30，TGFbeta-RII，TBR-Ii，LDS1B，LDS2B，TAAD2，TBRII，AAT3，FAA3，LDS2，RIIC，MFS2，Receptor， Transforming Growth Factor-beta Type II，EC:2.7.11.30
시판 약물 수	0
임상 약물 수	8
최고 연구 개발 단계	Phase 3 Clinical

TGF-beta RII 제품 목록

속성
Protein (6)
제품 라이브러리
온라인 (6)
종
Human (5)Mouse (1)
태그
Fc Tag (1)Fc Tag & Avi Tag (1)His Tag & Avi Tag (2)His Tag (1)Llama IgG Fc Tag (1)
마커
Unconjugated (3)Biotin-labeled (3)

제품 번호	종	발현 시스템	제품 설명
HOT TG2-H52H5	Human	HEK293	Human TGF-beta RII / TGFBR2 Protein, His Tag, low endotoxin (MALS verified)
HOT TG2-H82E4	Human	HEK293	Biotinylated Human TGF-beta RII / TGFBR2 Protein, His,Avitag™ (HPLC verified)
HOT TG2-M82H5	Mouse	HEK293	Biotinylated Mouse TGF-beta RII / TGFBR2 Protein, His,Avitag™ (MALS verified)
TG2-H5252	Human	HEK293	Human TGF-beta RII / TGFBR2 Protein, Fc Tag (MALS verified)
TG2-H5253	Human	HEK293	Human TGF-beta RII / TGFBR2 Protein, Llama IgG2b Fc Tag, low Endotoxin (MALS verified)
TG2-H82F6	Human	HEK293	Biotinylated Human TGF-beta RII / TGFBR2 Protein, Fc,Avitag™ (MALS verified)

총 수량6

TGF-beta RII분자 배경

TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

TGF-beta RII분자 별명

TGFBR2,TGFR2,TbetaR-II,TGFβR2

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
INCA-33890	INCA33890; INCA-33890	Phase 3 Clinical	Incyte Corp	Colorectal Neoplasms; Ovarian Neoplasms; Solid tumours	상세
HCW-9218	HCW-9218	Phase 2 Clinical	HCW Biologics Inc	Ovarian Neoplasms; Pancreatic Neoplasms; Pulmonary Fibrosis; Solid tumours	상세
TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy (The University Of Texas MD Anderson Cancer Center)		Phase 2 Clinical	The University Of Texas MD Anderson Cancer Center	Carcinoma; Colorectal Neoplasms; Neoplasm Metastasis	상세
TGFBR2 KO CAR27/IL-15 NK cells therapy (The University Of Texas MD Anderson Cancer Center)		Phase 2 Clinical	The University Of Texas MD Anderson Cancer Center	Hodgkin Disease; Lymphatic Diseases; Pancreatic Neoplasms	상세
TGFBR-2 KO CD70 CAR NK cell therapy (The University Of Texas MD Anderson Cancer Center)		Phase 1 Clinical	The University Of Texas MD Anderson Cancer Center	Adenocarcinoma, Clear Cell	상세
Autologous TGF-betaR2KO/IL13R-alpha2-CAR T cells Therapy(City of Hope Medical Center)		Phase 1 Clinical	City Of Hope National Medical Center	Astrocytoma; Glioblastoma	상세
RG-6315	RG-6315	Phase 1 Clinical	Genentech Inc	Scleroderma, Systemic	상세
TASO-001	TASO-001; ATB-301	Phase 1 Clinical	Autotelicbio Co Ltd	Solid tumours	상세

제품 리뷰

A***n2022-07-30
0사람들이 좋아합니다
Human TGF-beta RII / TGFBR2 Protein, His Tag, low endotoxin (MALS verified)
I ordered Acro’s human TGF-beta Receptor II for Octet kinetics binding assays for several assays. Delivery was extremely quick and customer service was very responsive to questions I had. I first used this TGF-beta RII in an Octet binding kinetics assay and received high quality results that were consistent with what I expected. I also used this product as a TGF-beta sink in cytotoxicity assays. I have been impressed by the quality of Acro’s products.