언어 선택

TFPI-2

TFPI-2 분자 정보

영어 이름	DNA-(apurinic or apyrimidinic site) lyase	시판 약물 수	0
임상 약물 수	1	표적 별명	AP endonuclease 1，DNA-(apurinic or apyrimidinic site) lyase，APE1，APEN，REF-1，Apurinic-apyrimidinic endonuclease 1，APEX nuclease，REF1，APEX，APEX1，Apurinic/Apyrimidinic Endodeoxyribonuclease 1，APEX Nuclease (Multifunctional DNA Repair Enzyme) 1，Redox Factor-1，HAP1，APE，APX，APEX Nuclease (Multifunctional DNA Repair Enzyme)，Deoxyribonuclease (Apurinic Or Apyrimidinic)，Apurinic/Apyrimidinic (Abasic) Endonuclease，AP Endonuclease Class I，Protein REF-1，AP Lyase，APE-1，DNA-(apurinic or apyrimidinic site) endonuclease
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	DNA-(apurinic or apyrimidinic site) lyase
표적 별명	AP endonuclease 1，DNA-(apurinic or apyrimidinic site) lyase，APE1，APEN，REF-1，Apurinic-apyrimidinic endonuclease 1，APEX nuclease，REF1，APEX，APEX1，Apurinic/Apyrimidinic Endodeoxyribonuclease 1，APEX Nuclease (Multifunctional DNA Repair Enzyme) 1，Redox Factor-1，HAP1，APE，APX，APEX Nuclease (Multifunctional DNA Repair Enzyme)，Deoxyribonuclease (Apurinic Or Apyrimidinic)，Apurinic/Apyrimidinic (Abasic) Endonuclease，AP Endonuclease Class I，Protein REF-1，AP Lyase，APE-1，DNA-(apurinic or apyrimidinic site) endonuclease
시판 약물 수	0
임상 약물 수	1
최고 연구 개발 단계	Phase 2 Clinical

TFPI-2 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
TF2-H5227	Human	HEK293	Human TFPI-2 Protein, His Tag

총 수량1

TFPI-2분자 배경

Tissue Factor Pathway Inhibitor 2 (TFPI2) is also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF1), is a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). TFPI2 is highly abundant in the full-term placenta and widely expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa and has no effect on thrombin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.

TFPI-2분자 별명

TFPI2,PP5,REF1

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
APX-3330	APX-3330; APX3330; E-3330	Phase 2 Clinical	Eisai Co Ltd	Solid tumours; Inflammatory Bowel Diseases; Neoplasms; Diabetic macular oedema; Diabetic Retinopathy	상세