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TACI

TACI Overview

English Name	Tumor necrosis factor receptor superfamily member 13B	Approved Drugs	0
Drugs in Clinical Trials	0	Target Synonym	Transmembrane activator and CAML interactor，CD267，TACI
Highest Development Stage	Preclinical

English Name	Tumor necrosis factor receptor superfamily member 13B
Target Synonym	Transmembrane activator and CAML interactor，CD267，TACI
Approved Drugs	0
Drugs in Clinical Trials	0
Highest Development Stage	Preclinical

TACI Product List

Product Category
Protein (6)Cell (1)
Product Status
Launched (7)
Species
Human (7)
Tag
Fc Tag & Avi Tag (1)Fc Tag (2)His Tag (1)- (2)His Tag & Avi Tag (1)
Conjugate
Biotin-labeled (3)Unconjugated (3)- (1)

Cat. No.	Species	Host	Product Description
HOT TAI-H52H3	Human	HEK293	Human TACI / TNFRSF13B Protein, His Tag, low endotoxin
CHEK-ATF197	Human	HEK293	Human TACI (Luc) HEK293 Reporter Cell
TAI-H5253	Human	HEK293	Human TACI / TNFRSF13B (R119A, R122A) Protein, Fc Tag (MALS verified)
TAI-H5254	Human	HEK293	Human TACI / TNFRSF13B Protein, Fc Tag (HPLC verified)
TAI-H82E3	Human	HEK293	Biotinylated Human TACI / TNFRSF13B Protein, His,Avitag™ (MALS verified)
TAI-H82F6	Human	HEK293	Biotinylated Human TACI / TNFRSF13B Protein, Fc,Avitag™
TAL-H82F3	Human	HEK293	Biotinylated Human TACI / TNFRSF13B Protein, Fc,Avitag™ (MALS verified)

Total: 7

TACI Background

Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B). It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. The present study demonstrated that, in NSCLC, a proliferation-inducing ligand (APRIL), B-cell maturation antigen (BCMA)and transmembrane activator and CAML interactor (TACI) proteins are abnormally expressed by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blotting. In addition, the expression of APRIL, BCMA and TACI were observed to be involved in extracellular signal-regulated kinase (ERK)1/2 activation in A549 cells.