언어 선택

SSTR2

SSTR2 분자 정보

영어 이름	Somatostatin receptor 2	시판 약물 수	7
임상 약물 수	27	표적 별명	Somatostatin receptor type 2，SS-2-R，SS2R，SSTR2，Somatostatin Receptor 2，SRIF-1，SS2-R
최고 연구 개발 단계	Approved

영어 이름	Somatostatin receptor 2
표적 별명	Somatostatin receptor type 2，SS-2-R，SS2R，SSTR2，Somatostatin Receptor 2，SRIF-1，SS2-R
시판 약물 수	7
임상 약물 수	27
최고 연구 개발 단계	Approved

SSTR2 제품 목록

속성
Protein (2)Cell (1)
제품 라이브러리
온라인 (3)
종
Human (3)
태그
- (2)GFP Tag (1)
마커
Unconjugated (1)GFP Fusion (1)- (1)

제품 번호	종	발현 시스템	제품 설명
CHEK-ATP213	Human	HEK293	HEK293/Human SSTR2 Stable Cell Line
SS2-H5216	Human	HEK293	Human SSTR2 Full Length Protein (VLP)
SS2-HF2G3	Human	HEK293	Fluorescent Human SSTR2 Full Length Protein (VLP)

총 수량3

SSTR2분자 배경

Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an invaluable drug target for the pharmacological management of pituitary adenomas and neuroendocrine tumors. Somatostatin receptors (SSTR1, 2A and B, 3, 4 and 5) belong to the G protein coupled receptor family and have a wide expression pattern in both normal tissues and solid tumors. Investigating the function of each SSTR in several tumor types has provided a wealth of information about the common but also distinct signaling cascades that suppress tumor cell proliferation, survival and angiogenesis. This provided the rationale for developing multireceptor-targeted somatostatin analogs and combination therapies with signaling-targeted agents such as inhibitors of the mammalian (or mechanistic) target of rapamycin (mTOR). The ability of SSTR to internalize and the development of rabiolabeled somatostatin analogs have improved the diagnosis and treatment of neuroendocrine tumors.

SSTR2분자 별명

Smstr2,Somatostatin R2,somatostatin receptor 2,somatostatin receptor type 2,SomatostatinR2,SRIF-1,SS2R,SS-2-R,SS2-R,SST2,SSTR2

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Lutetium-177 labelled edotreotide	ITM-11	Phase 3 Clinical	Itm Solucin Gmbh, Universitaetsspitals Basel	Central Nervous System Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Stromal Tumors; Lymphoma; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Carcinoma of Lung; Neuroendocrine Tumors; Pancreatic neuroendocrine tumors (pNET); Rhabdomyosarcoma; Solid tumours; Thymus Neoplasms	상세
Actinium-225 Dotate	225Ac-DOTATATE; RYZ-101; [225Ac]Ac-DOTATATE	Phase 3 Clinical	RayzeBio Inc	Breast Neoplasms; Carcinoid Tumor; Carcinoma, Neuroendocrine; Gastroenteropancreatic neuroendocrine tumor; Meningioma; Metastatic breast cancer; Multiple Myeloma; Neuroendocrine Tumors; Small Cell Lung Carcinoma	상세
Lutetium-177 DOTA satoreotide	OPS-201; 177LU-OPS 201; 177Lu-DOTA- JR11; 177Lu-satoreotide; 177Lu-IPN01072; [177Lu]LuSSO110; 177Lu-IPN-1072; 177Lu SSO 110	Phase 2 Clinical	OctreoPharm Sciences GmbH	Breast Neoplasms; Meningioma; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma	상세
Yttrium 90-labelled edotreotide	SMT-487-[90Y]; DOTATOC-[90Y]	Phase 2 Clinical	Novartis Pharma Ag, The University Of Iowa	Adenoma, Islet Cell; Breast Neoplasms; Carcinoid Tumor; CNS Embryonal Tumor; Lung Neoplasms; Lymphoma; Medulloblastoma; Meningioma; Neoplasms; Neuroblastoma; Neuroendocrine Tumors; Pheochromocytoma; Sarcoma; Skin Melanoma; Solid tumours	상세
ZT-01	ZT 01; ZT-01	Phase 2 Clinical	Tulane University, University Of Toronto, Toronto, York University	Diabetes Mellitus, Type 1; Hypoglycemia	상세
Terbium 161 DOTATATE PRRT		Phase 2 Clinical	Tata Memorial Centre	Carcinoma, Neuroendocrine; Neuroendocrine Tumors	상세
Al18F-NOTA-LM3	Al18F-NOTA-LM3	Phase 2 Clinical	Peking Union Medical College Hospital	Neuroendocrine Tumors	상세
68Ga-HA-DOTATATE	68Ga-HA-DOTATATE	Phase 2 Clinical	University Of Alberta	Neuroendocrine Tumors	상세
Re-188 P 2045	Rhenium-188 P2045; Rhenium-188-P-2045; Re-188 P 2045; Rh-188 P2045; Rhenium 188 P2045; P2045; BAY-865284	Phase 2 Clinical	Bayer AG	Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Lung Neoplasms; Neoplasm Recurrence, Local; Neuroendocrine Tumors; Small Cell Lung Carcinoma	상세
CRN-09682	CRN-09682; CRN09682	Phase 2 Clinical	Crinetics Pharmaceuticals Inc	Carcinoma, Neuroendocrine; Neuroendocrine Tumors	상세
MB-0151		Phase 2 Clinical	Mainline Biosciences (Shanghai) Co Ltd, Zhongshan Zhuliuyuan Biotechnology Co Ltd	Solid tumours	상세
177Lu-LNC1010	177Lu-LNC1010	Phase 2 Clinical	Yantai Lannacheng Biotechnology Co Ltd	Neoplasms; Neuroendocrine Tumors; Pancreatic neuroendocrine tumors (pNET); Solid tumours	상세
[203-Pb] VMT-NET	[203-Pb] VMT-NET	Phase 2 Clinical	Perspective Therapeutics Inc	Carcinoma, Renal Cell; Head and Neck Neoplasms; Neuroendocrine Tumors; Paraganglioma; Pheochromocytoma; Small Cell Lung Carcinoma	상세
64Cu-SarTate		Phase 2 Clinical	Clarity Pharmaceuticals Ltd, University Of Melbourne	Neuroendocrine Tumors	상세
Gallium-68 satoreotide	68Ga-DOTA-JR11; 68Ga-SSO-120; 68Ga IPN-1070; 68Ga-OPS-202	Phase 1 Clinical	Ipsen Inc	Breast Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Small Cell Lung Carcinoma	상세
68Ga-NOTA-3PTATE-RGD	68Ga-NOTA-3P-TATE-RGD; 68Ga-NOTA-3PTATE-RGD	Phase 1 Clinical	Peking Union Medical College Hospital	Carcinoma, Neuroendocrine; Lung Neoplasms; Meningioma; Neuroendocrine Tumors	상세
[68Ga]Ga-FL-031		Phase 1 Clinical	Full Life Technologies Ltd	Neoplasms	상세
NTQ-6179	NTQ-6179	Phase 1 Clinical	Nanjing Zhengda Tianqing Pharmaceutical Co Ltd	Acromegaly; Neuroendocrine Tumors	상세
68Ga-DOTA-LM3	68Ga-DOTA-LM3	Phase 1 Clinical	Peking Union Medical College	Neuroendocrine Tumors	상세
68Ga-NODAGA-LM3	68Ga-NODAGA-LM3	Phase 1 Clinical	Peking Union Medical College	Neuroendocrine Tumors	상세
177Lu-DOTA-LM3	177Lu-DOTA-LM3	Phase 1 Clinical	Zentralklinik Bad Berka	Neuroendocrine Tumors	상세
177Lu-TATE-RGD	177Lu-TATE-RGD	Phase 1 Clinical	Peking Union Medical College Hospital	Neoplasms	상세
[99mTc]Tc-TECANT1		Phase 1 Clinical	Jagiellonian University Sylff Fellows Association, Ljubljana University Medical Centre, Medical University Of Innsbruck, Narodowe Centrum Badan Jadrowych	Neuroendocrine Tumors	상세
161Tb-DOTA-LM3	161Tb-DOTA-LM3	Phase 1 Clinical	University Hospital Basel	Gastroenteropancreatic neuroendocrine tumor; Neuroendocrine Tumors	상세
44Sc-edotreotide	Sc44-DOTATOC; 44Sc-DOTA-[3-Tyr]-octreotide; 44Sc-edotreotide	Clinical	Zentralklinik Bad Berka	Diagnostic agents	상세
68Ga-FAPI-LM3	68Ga-FAPI-LM3	Clinical	The First Affiliated Hospital Of Xiamen University	Adenomatous Polyposis Coli	상세
225AcDOTA-LM3	225AcDOTA-LM3	Clinical	CURANOSTICUM Wiesbaden-Frankfurt	Pancreatic neuroendocrine tumors (pNET)	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Pasireotide Pamoate		Approved	Novartis Pharma Ag	Signifor lar	United States	Acromegaly	Recordati Rare Diseases Inc	2014-12-15	Acromegaly; Carcinoid Tumor; Cushing Syndrome; Gigantism; Meningioma; Neuroendocrine Tumors; Pituitary ACTH Hypersecretion	상세
Lutetium (177Lu) oxodotreotide	Lu-DOTATATE; 177Lu-DOTATATE; [Lu-177]-DOTATATE; AAA-601; F-1515; XTR-008; [177Lu]Lu-DOTA-TATE; Lutetium (177Lu) DOTA-TATE	Approved	Advanced Accelerator Applications Sa	Lutathera	EU	Neuroendocrine Tumors	Advanced Accelerator Applications Sa	2017-09-26	Adenoma, Islet Cell; Breast Neoplasms; Bronchial Neoplasms; Carcinoid Heart Disease; Carcinoma, Neuroendocrine; Gastroenteropancreatic neuroendocrine tumor; Leiomyosarcoma; Liver Neoplasms; Malignant Carcinoid Syndrome; Medullary thyroid cancer (MTC); Meningioma; Metastatic breast cancer; Neuroblastoma; Neuroendocrine Carcinoma of Lung; Neuroendocrine Tumors; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Paraganglioma; Pheochromocytoma; Pituitary Neoplasms; Prostatic Neoplasms; Small Cell Lung Carcinoma	상세
Paltusotine	CRN-00808	Approved	Crinetics Pharmaceuticals Inc	PALSONIFY	United States	Acromegaly	Crinetics Pharmaceuticals Inc	2025-09-25	Acromegaly; Carcinoid Tumor; Cecal Neoplasms; Diarrhea; Ileal Neoplasms; Intestinal Neoplasms; Liver Neoplasms; Malignant Carcinoid Syndrome; Neuroendocrine Tumors; Pancreatic Neoplasms	상세
Vapreotide Acetate	RC-160; BMY-41606	Approved	Debiopharm Group	Sanvar, Docrised, Sanvar IR, Sanvar SR					Acromegaly; Crohn Disease; Diarrhea; Esophageal and Gastric Varices; Hemorrhage; Hypertension, Portal; Intraoperative Complications; Neuroendocrine Tumors; Pancreatic Neoplasms; Postoperative Complications	상세
Pasireotide Diaspartate	SOM-230; SOM-230C; SOM-320	Approved	Novartis Pharma Ag	Signifor, 丝尼芬	EU	Cushing Syndrome	Recordati Rare Diseases Inc	2012-04-24	Acromegaly; ACTH Syndrome, Ectopic; Adenoma, Islet Cell; Alcoholism; Carcinoid Tumor; Carcinoma, Hepatocellular; Cluster Headache; Congenital Hyperinsulinism; Cushing Syndrome; Cysts; Dumping Syndrome; Gastroenteropancreatic neuroendocrine tumor; Gastrointestinal Neoplasms; Hormone-Resistant Prostate Neoplasms; Hyperinsulinism; Hypoglycemia; Insulinoma; Liver Cirrhosis; Medullary thyroid cancer (MTC); Meningioma; Multiple Myeloma; Nelson Syndrome; Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Pituitary ACTH Hypersecretion; Pituitary Neoplasms; Post-bariatric Hypoglycemia; Prolactinoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Renal Insufficiency; Small Cell Lung Carcinoma; Thymoma; Thyroid Neoplasms; Uveal melanoma	상세
Ga-68 Edotreotide	SMT-487; [68Ga]DOTATOC; 68Ga-DOTATOC	Approved	Advanced Accelerator Applications Sa	SomaKit TOC, Gallium Dotatoc Ga 68, TOCscan	EU	Diagnostic agents; Neuroendocrine Tumors; Pancreatic neuroendocrine tumors (pNET)	Advanced Accelerator Applications Sa	2016-12-08	Breast Neoplasms; Carcinoid Tumor; Carcinoma, Neuroendocrine; Diagnostic agents; Medulloblastoma; Meningioma; Multiple Endocrine Neoplasia Type 1; Nasopharyngeal Carcinoma; Neuroblastoma; Neuroendocrine Tumors; Pancreatic neuroendocrine tumors (pNET); Paraganglioma; Pituitary Neoplasms; Solid tumours; Somatostatinoma; von Hippel-Lindau Disease	상세
Gallium (68Ga) oxodotreotide	68Ga-DOTA-TATE; 68-Ga-DOTA-TATE; AAA-501	Approved	Advanced Accelerator Applications Sa	Netspot	United States	Neuroendocrine Tumors	Aaa Usa Inc	2016-06-01	Carcinoid Tumor; Carcinoma, Neuroendocrine; Neuroendocrine Tumors; Pancreatic Neoplasms; Paraganglioma; Pheochromocytoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Thyroid Neoplasms; von Hippel-Lindau Disease	상세