언어 선택

Sortilin

Sortilin 분자 정보

영어 이름	Sortilin	시판 약물 수	0
임상 약물 수	3	표적 별명	100 kDa NT receptor，NT3，Glycoprotein 95，LDLCQ6，NTR3，Gp95，Sortilin 1，Neurotensin receptor 3
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Sortilin
표적 별명	100 kDa NT receptor，NT3，Glycoprotein 95，LDLCQ6，NTR3，Gp95，Sortilin 1，Neurotensin receptor 3
시판 약물 수	0
임상 약물 수	3
최고 연구 개발 단계	Phase 2 Clinical

Sortilin 제품 목록

속성
Protein (5)Cell (1)
제품 라이브러리
온라인 (6)
종
Human (3)Cynomolgus (1)Rat (1)Canine (1)
태그
His Tag (4)His Tag & Avi Tag (1)- (1)
마커
Unconjugated (4)Biotin-labeled (1)- (1)

제품 번호	종	발현 시스템	제품 설명
CHEK-ATP155	Human	HEK293	HEK293/Human SORT1 Stable Cell Line
SON-H52H5	Human	HEK293	Human Sortilin / SORT1 Protein, His Tag, low endotoxin (MALS verified)
SON-H82E9	Human	HEK293	Biotinylated Human Sortilin / SORT1 Protein, His,Avitag™ (MALS & SPR verified)
SON-C52H3	Cynomolgus	HEK293	Cynomolgus Sortilin Protein, His Tag
SON-C52H4	Canine	HEK293	Canine Sortilin Protein, His Tag
SON-R52H3	Rat	HEK293	Rat Sortilin Protein, His Tag (MALS verified)

총 수량6

Sortilin분자 배경

The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.

Sortilin분자 별명

Sortilin,SORT1,100 kDa NT receptor,Glycoprotein 95,Gp95,Gp95LDLCQ6,Neurotensin receptor 3,NT3NTR3,Ntr3,sortilin 1,

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
VES-001	VES001; VES-001	Phase 2 Clinical	Vesper Bio APS	Dementia; Frontotemporal Dementia; Frontotemporal Lobar Degeneration	상세
Latozinemab	AL-001; GSK-4527223	Phase 1 Clinical	Alector Inc, Glaxosmithkline Plc	Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Neurodegenerative Diseases	상세
ARB-1-6	ARB-1-6; PQ-203	Phase 1 Clinical	ProteinQure Inc	Breast Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	상세