언어 선택

Sonic Hedgehog

Sonic Hedgehog 분자 정보

영어 이름	Sonic Hedgehog Homolog	시판 약물 수	0
임상 약물 수	4	표적 별명	HHG-1，Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains，ShhNC，Shh N-terminal processed signaling domains，ShhNp，ShhN，Sonic hedgehog protein，Sonic hedgehog protein N-product，Sonic Hedgehog Signaling Molecule，Sonic Hedgehog (Drosophila) Homolog
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Sonic Hedgehog Homolog
표적 별명	HHG-1，Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains，ShhNC，Shh N-terminal processed signaling domains，ShhNp，ShhN，Sonic hedgehog protein，Sonic hedgehog protein N-product，Sonic Hedgehog Signaling Molecule，Sonic Hedgehog (Drosophila) Homolog
시판 약물 수	0
임상 약물 수	4
최고 연구 개발 단계	Phase 2 Clinical

Sonic Hedgehog 제품 목록

속성
Protein (4)
제품 라이브러리
온라인 (4)
종
Human (4)
태그
His Tag (1)Tag Free (3)
마커
Unconjugated (4)

제품 번호	종	발현 시스템	제품 설명
GMP-SH7H13	Human	E. coli	GMP Human Sonic Hedgehog / Shh (C24II) Protein
SH7-H5116	Human	E. coli	Human Sonic Hedgehog / Shh (C24II) Protein, premium grade
SH7-H5117	Human	E. coli	Human Sonic Hedgehog / Shh (C24II) Protein, Research Grade
SH7-H5229	Human	HEK293	Human Sonic Hedgehog / Shh Protein, His Tag, premium grade

총 수량4

Sonic Hedgehog분자 배경

Sonic hedgehog protein (SHH) is also known as HHG-1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein N-product and sonic hedgehog protein C-product by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.

Sonic Hedgehog분자 별명

SHH,HHG-1,Sonic hedgehog,HLP3,HPE3,SMMCI,TPT,TPTPS

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
ACC-006	ACC-006	Phase 2 Clinical	China Pharmaceutical University, Jiangsu Aidea Pharmaceutical Group Co Ltd	Carcinoma, Non-Small-Cell Lung; Solid tumours	상세
Sulforafan alfadex	SFX-01; STP-2	Phase 2 Clinical	Evgen Pharma, Lalilab, Pharmagra Labs Inc	Asthma; Autism Spectrum Disorder; Autistic Disorder; Breast Neoplasms; Carcinoma in Situ; Drug-Related Side Effects and Adverse Reactions; Head and Neck Neoplasms; Heart Diseases; Heart Failure, Diastolic; Hyperplasia; Kidney Diseases; Lung Neoplasms; Melanoma; Nasolabial fold wrinkles; Neoplasms; Neurodevelopmental Disorders; Parkinson Disease; Precancerous Conditions; Prostatic Neoplasms; Renal Insufficiency, Chronic; Schizophrenia; Squamous Cell Carcinoma of Head and Neck; Subarachnoid Hemorrhage; Ventricular Dysfunction, Left	상세
NLM-001	NLM-001; TAK-441	Phase 2 Clinical	Millennium Pharmaceuticals Inc	Carcinoma, Basal Cell; Carcinoma, Pancreatic Ductal; Neoplasms	상세
IMP5471-CA		Phase 1 Clinical	Shanghai Impact Pharmaceutical Co Ltd	Hematologic Diseases	상세