언어 선택

SMN1

SMN1 분자 정보

영어 이름	Survival motor neuron protein	시판 약물 수	3
임상 약물 수	9	표적 별명	Survival Of Motor Neuron 1 Isoform D345，Survival Of Motor Neuron 1 Isoform D2A2B3457，Survival Of Motor Neuron 1 Isoform D347，SMN1 more，SMN1，Survival Of Motor Neuron 1 Isoform D3457，Survival Of Motor Neuron 1， Telomeric，Gemin-1，Tudor Domain Containing 16A，SMNT，SMN，Survival Motor Neuron 1 Protein，Survival Motor Neuron Protein，T-BCD541，TDRD16A，BCD541，GEMIN1，SMA1，SMA2，SMA3，SMA4，SMA@，SMA，SMN Complex Proteins，Component of gems 1，SMN2，SMNC，Survival Of Motor Neuron 1 Isoform D2B3457，Survival Of Motor Neuron 1 Isoform D2A3457，Spinal Muscular Atrophy (Werdnig-Hoffmann Disease， Kugelberg-Welander Disease)，Survival Of Motor Neuron 1 Isoform D2A2B345
최고 연구 개발 단계	Approved

영어 이름	Survival motor neuron protein
표적 별명	Survival Of Motor Neuron 1 Isoform D345，Survival Of Motor Neuron 1 Isoform D2A2B3457，Survival Of Motor Neuron 1 Isoform D347，SMN1 more，SMN1，Survival Of Motor Neuron 1 Isoform D3457，Survival Of Motor Neuron 1， Telomeric，Gemin-1，Tudor Domain Containing 16A，SMNT，SMN，Survival Motor Neuron 1 Protein，Survival Motor Neuron Protein，T-BCD541，TDRD16A，BCD541，GEMIN1，SMA1，SMA2，SMA3，SMA4，SMA@，SMA，SMN Complex Proteins，Component of gems 1，SMN2，SMNC，Survival Of Motor Neuron 1 Isoform D2B3457，Survival Of Motor Neuron 1 Isoform D2A3457，Spinal Muscular Atrophy (Werdnig-Hoffmann Disease， Kugelberg-Welander Disease)，Survival Of Motor Neuron 1 Isoform D2A2B345
시판 약물 수	3
임상 약물 수	9
최고 연구 개발 단계	Approved

SMN1 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
SM1-H5145	Human	E. coli	Human SMN1 Protein, His Tag

총 수량1

SMN1분자 배경

SMN1 is produced chiefly by the SMN1 gene, located on the telomeric portion of chromosome 5q. SMN1 protein is one of a group of proteins called the SMN complex, which is important for the maintenance of specialized nerve cells called motor neurons. In cells, the SMN complex plays an important role in processing mRNA. The SMN complex helps to assemble the cellular machinery needed to process pre-mRNA. The SMN complex is also important for the development of specialized outgrowths from nerve cells called dendrites and axons. Deletion or mutation of the SMN1 gene results in a reduced level of full-length SMN protein and manifests as a range of neuromuscular phenotypes in humans as the disease spinal muscular atrophy (SMA).

SMN1분자 별명

Survival Motor Neuron 1,SMN1

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
vesemnogene lantuparvovec	AAV-hSMN1	Phase 3 Clinical	Lantu Biopharma Inc	Muscular Atrophy, Spinal	상세
Salanersen	BIIB-115; ION-306	Phase 3 Clinical	Ionis Pharmaceuticals Inc	Muscular Atrophy, Spinal	상세
Branaplam	LMI-070; NVP-LMI070-AAA; NVP-LMI070-NX; NVS-SM1	Phase 2 Clinical	Novartis Pharma Ag	Huntington Disease; Muscular Atrophy, Spinal	상세
GB-221 (GEMMA Biotherapeutics)	GB-221	Phase 2 Clinical	Gemma Biotherapeutics Inc	Spinal Muscular Atrophies of Childhood	상세
ANB-004	ANB-004	Phase 2 Clinical	BIOCAD JSC	Muscular Atrophy, Spinal	상세
EXG001-307	EXG001-307	Phase 2 Clinical	Exegenesis Bio Inc	Muscular Atrophy, Spinal	상세
SMN-C3	SMN-C3	Phase 1 Clinical	F. Hoffmann-La Roche Ltd, Ptc Therapeutics Inc	Muscular Atrophy, Spinal	상세
SKG-0201	SKG-0201; SKG0201	Phase 1 Clinical	Skyline Therapeutics (Hong Kong) Ltd	Muscular Atrophy, Spinal; Spinal Muscular Atrophies of Childhood	상세
GCB-001	GCB-001; GCB001	Clinical	Shanghai Jinke Bo Biotechnology Co Ltd	Spinal Muscular Atrophies of Childhood	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Risdiplam	RG-7916; RO-7034067	Approved	Ptc Therapeutics Inc	EVRYSDI, 艾满欣	United States	Muscular Atrophy, Spinal	Genentech Inc	2020-08-07	Muscular Atrophy, Spinal	상세
Nusinersen sodium	BIIB-058; ISIS-396443	Approved	Ionis Pharmaceuticals Inc	Spinraza	United States	Muscular Atrophy, Spinal	Biogen Idec	2016-12-23	Muscular Atrophy, Spinal	상세
Onasemnogene abeparvovec	AVXS-101; scAAV-9.CB.SMN; OAV101; rAAV-9	Approved	Novartis Gene Therapies Inc, Novartis Pharma Ag	Zolgensma, Itvisma	United States	Muscular Atrophy, Spinal	Novartis Gene Therapies Inc	2019-05-24	Muscular Atrophy, Spinal; Spinal Muscular Atrophies of Childhood	상세