언어 선택

SMAC

SMAC 분자 정보

영어 이름	Diablo homolog, mitochondrial	시판 약물 수	0
임상 약물 수	1	표적 별명	Direct IAP-binding protein with low pI，Second mitochondria-derived activator of caspase，Smac，Diablo IAP-Binding Mitochondrial Protein
최고 연구 개발 단계	Phase 1 Clinical

영어 이름	Diablo homolog, mitochondrial
표적 별명	Direct IAP-binding protein with low pI，Second mitochondria-derived activator of caspase，Smac，Diablo IAP-Binding Mitochondrial Protein
시판 약물 수	0
임상 약물 수	1
최고 연구 개발 단계	Phase 1 Clinical

SMAC 제품 목록

속성
Protein (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
His Tag (1)
마커
Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
DIO-H5129	Human	E. coli	Human SMAC / Diablo Protein, His Tag

총 수량1

SMAC분자 배경

Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.